Cancer Care Engineering

Overview

The War on Cancer was launched in 1971 when President Nixon signed the National Cancer Act. In the ensuing years, remarkable advances have been made in the molecular understanding of cancer and the wide-spread implementation of screening protocols for early detection. However, major scientific advances have not translated into expected large declines in mortality resulting from cancer. The current challenge is to focus the rapid and extraordinary advances using large scale human OMIC analyses (genomics, proteomics, metabolomics, etc.) to significantly improve survival rates in community-based oncology clinics and develop community-wide prevention efforts.

The Cancer Care Engineering (CCE) vision addresses this challenge by applying systems engineering principles and unique data visualization and statistical model building to the broad spectrum of cancer prevention, treatment, and care delivery. The core of the CCE project is based on visualizing cancer, from the development of the disease to the delivery of care, as a system that can be mathematically described and modeled using principles of systems engineering and novel statistical analyses. The power of this systems engineering approach is that the behavior of a system that can be mathematically described and modeled, can be predicted. The ability to predict responses within the cancer system has staggering implications, from the capability to classify patients based on their predicted response to potential treatments, to the design of more efficient and effective delivery of cancer care.

The CCE project is a collaborative effort between Purdue University (led by the OSC), Indiana University Simon Cancer Center, and the Regenstrief Institute/ Indiana University Center for Health Services & Outcomes Research. The CCE project is funded by the Regenstrief Foundation and the Department of Defense. More information on this mega-project can be found at www.ccehub.org.

In February 2009, the CCE project lost our leader, Dr. Stephen D. Williams, to his own battle with cancer. We continue the CCE project in his memory. Dr. Williams was a gifted physician, leader and a dear friend.

People

Kathy Abrahamson, Roudebush VAMC

Jiri Adamec, Purdue University

George Allen, Roudebush VAMC

Sunil Badve, Indiana University School of Medicine

Darrell Baker, Roudebush VAMC

Donald E. Bergstrom, Purdue University

Athman Bouguettaya, Virginia Tech

Patrick Boyle, Purdue University

D. Scott Brandt, Purdue University

Charles Buck, Purdue University

John Burr, Purdue University

Matthew Burton, Regenstrief Institute, Inc

Tim Carney, Roudebush VAMC

Ann Catlin, Purdue University

Naga Chalasani, Indiana University School of Medicine

Jake Chen, IUPUI

Wei Chen, Purdue University

Gabi Chiorean, Indiana University School of Medicine

William Cleveland, Purdue University

Chris Clifton,Purdue University

Bruce Craig, Purdue University

Oscar Cummings, Indiana University School of Medicine

Michael Darling, Indiana University School of Medicine

Tapas Das, University of South Florida

Leonard D'Avolio, Northeastern University

Caroline Doebbeling, Indiana Office of Medicaid Planning and Policy

Bradley Doebbeling, Indiana University School of Medicine

David Ebert, Purdue University

Ahmed Elmagarmid, Purdue University

David Flockhart, Indiana University School of Medicine

Barbara Fossum, Purdue University

Rebekah Fox, Roudebush VAMC

Chaitra Gopalappa, Purdue University

David Haggstrom, Roudebush VAMC

Stan Hamilton, MD Anderson Cancer Center

Marietta L. Harrison, Purdue University

Jennifer Hoffman, Regenstrief Institute, Inc

Ned Howell, Purdue University

Thomas Imperiale, Indiana University School of Medicine

Krishna Jayakumar, Purdue University

Laura Jones Myers, Roudebush VAMC

Charles Kahi, Roudebush VAMC

Mark Kelley, Indiana University School of Medicine

Perry Kirkham, Purdue University

James E. Klaunig, Indiana University School of Medicine

Deborah Knapp, Purdue University

Renata Knorad, Purdue University

Patrick Loehrer, Indiana University School of Medicine

Lori Losee, Roudebush VAMC

Tanu Malik, Purdue University

Brandies Marshall, Purdue University

Stacey Mobley, Purdue University

Ken Musselman, Purdue University

Julie Nagel, Purdue University

Nadine Najjar, Regenstrief Institute, Inc

Kelli Nortonm, Regenstrief Institute, Inc

Seza Orcun, Purdue University

Mourad Ouzzani, Purdue University

Matthew Palakal, IUPUI

Joseph Pekny, Purdue University

Sunil Prabhakar, Purdue University

Meeta Pradhan, IUPUI

Daniel Raftery, Purdue University

Doraiswami Ramkrishna, Purdue University

Fred Regnier, Purdue University

Diane C. Rein, Purdue University

Paige Riley, Purdue University

Steve Roberts, Indiana University School of Medicine

Marc Rosenman, Indiana University School of Medicine

Ann Rundell, Purdue University

Jason Saleem, Roudebush VAMC

Katherine Schilling, Indiana University

Eric Sherer, Roudebush VAMC

Maribeth Sledodnik, Purdue University

Kris Swank, Purdue University

Dorothy Teegarden, Purdue University

Reha Uzsoy, North Caroline State University

Steve Witz, Purdue University

Heather Woodward-Hagg, Roudebush VAMC

Jamie Workman-Germann, IUPUI

Yan Xu, Indiana University School of Medicine

Jose Zayas-Castro, University of South Flordia

Dabao Zhang, Purdue University

Jian Zhang, Purdue University

Min Zhang, Purdue University