Discovery Park Impact

Progress in bioscience and biomedical research requires innovative instruments with new capabilities. One instrument with great potential in several research fields is the mass spectrometer. Mass spectrometry has provided powerful progress in biomedical, food safety, and defense applications, but the original instrumentation was confined to laboratories because the instrument weighs hundreds of pounds and requires extensive and complicated support systems.

Dr. R. Graham Cooks and his research teams have pursued the miniaturization of this technology for the past decade. Additionally, his group invented the unique desorptive electrospray ionization (DESI) method that enables sample analysis outside the laboratory without special preparation of samples.

First, Dr. Cooks and his research team developed a smaller technology that was licensed for defense applications by a start-up company, Griffin Analytical. Griffin Analytical has been so successful that it was recently acquired by a large company, icx technologies.

Second, a few years later, another start-up company, Prosolia, licensed the DESI application and is now developing and manufacturing this and other ambient ionization sources for commercially available mass spectrometers. Prosolia continues to work with Discovery Park to further develop the sensitivity of this technique and new applications.

Third, Dr. Cook's instrumentation developments are one of the technological strengths that led to the creation through Discovery Park's Bindley Bioscience Center of the Center for Analytical Instrumentation Development (CAID). This Center includes faculty research teams at Purdue, Indiana University, the University of Notre Dame, and the University of Illinois, Urbana-Champaign. The goal of the center is to: "Lead America in creating the next generation of innovative 'machine-tools of science' that enable discoveries across the life sciences." For example, Griffin Analytical staff continue to work with CAID to prototype miniature mass spectrometry products through a major research and development partnership. CAID was the backdrop for the recent development of rapid, highly sensitive tests for melamine, the toxic protein mimic molecule found in counterfeit infant formula in China.

CAID researchers are producing smaller mass spectrometers with multiple uses. With Dr. Zhang Ouyang at Purdue, a fully self-contained mass spectrometer about the size of a kid's shoe box that weighs 10 pounds has been developed that has full mass spectrometry capabilities. This instrument was recently profiled in "CSI: Miami." An article about the technology was published in Science in August 2008. The instrument provides a "molecular fingerprint" which not only identifies an individual's fingerprint, but can unearth fingerprints buried below the surface print. Importantly, the fingerprint itself is comprised of chemical substances handled by the individual that are detected by the instrument -for example, compounds found in drugs or explosives.

Dr. Cooks' research teams are not finished. He believes that miniature DESI mass spectrometry will be used to locate tumor margins during surgical procedures, for better understanding of drug distributions in the body, and for additional chemical, defense, and forensic applications. Dr. Cooks believes that someday we may all own a personal chemical analyzer based on this technology to monitor personal health and environmental conditions.

The state of Indiana is positioned to attract new companies and start-ups, especially those companies in the life sciences sector tapping many existing Indiana assets.

Purdue's Discovery Park is a draw for venture capitalists interested in tapping into the deep expertise and capabilities of Purdue University. The Bindley Bioscience Center offers both cutting edge instrumentation and brings together multi-disciplinary Purdue expertise to collaborate on research projects. In late 2007, Clarian Health Ventures began their Indianapolis operations and approached staff in the Bindley Bioscience Center regarding strategic relationships around biomedical investments. An opportunity arose to explore these relationships arose with PDS Biotechnology, a company formed around innovative liposome drug delivery technology from the University of Cincinnati. Clarian Health Ventures was interested in PDS Biotechnology and encouraged them to consider relocation to Indiana. In a partnership with the state of Indiana's Indiana Economic Development Corporation, the Bindley Bioscience Center hosted PDS Biotechnology for a visit that included introduction to the resources at Discovery Park and the Purdue Research Park. PDS Technology was impressed with the expertise of the Purdue research teams as well as the Discovery Park infrastructure that includes the Birck Nanotechnology Center. PDS Biotechnology was interested in nanotechnology fabrication capabilities, the atmosphere of collaboration, and the support for research translation found at Discovery Park and the Purdue Research Park.

On January 19th, 2009, PDS Biotechnology announced the decision to relocate its Cincinnati operations to Indiana.

About PDS Biotechnology Corporation

PDS Biotechnology Corporation is a biopharmaceutical company pioneering the development of safe, simple, potent and targeted immunotherapies for the treatment of cancer and infectious diseases. Unlike typical cancer and antiviral immunotherapies, the patented nanoparticle VersamuneTM technology both facilitates the uptake of disease-associated proteins and peptides by the cells of the immune system and simultaneously activates the immune system to generate a strong and specific immune response against the infected cells in the body, resulting in eradication of the cancer or viral disease. For more information about PDS Biotechnology, visit www.pdsbiotech.com.

The Burton D. Morgan Center for Entrepreneurship serves in the leadership role for Purdue University's Business Plan Competitions: the Burton D. Morgan Competition, the Life Sciences Competition, and the Social Entrepeneurship-I2P-Compeition. These competitions provide an environment for emerging entrepreneurs to obtain professional feedback on their ideas and business plans, compete for funding, receive in-kind professional services, and be granted space in the Purdue Research Park.

The Burton D. Morgan Business Plan Competition was initiated in 1987 by the Krannert School of Management through a generous gift by Burton D. Morgan, a 1938 Purdue graduate. The competition provides resources for the construction of a viable business plan. Judges selected to evaluate participants' business plans represent the many constituencies comprising the entrepreneurship world, including venture capitalists, lawyers, accountants, consultants, and successful entrepreneurs. This competition is a model for the other programs sponsored by the Burton D. Morgan Center for Entrepreneurship. Each year, the competition culminates with five teams from the undergraduate student division and five teams from the graduate student division awarded finalist status and making formal presentations to the judges.

Since the Burton D. Morgan Competition began in 1987, it has made a mark in Indiana:

• 33 of 132 cumulative finalists initiated steps to start the Venture proposed in the Competition
• Of these 33 finalists, 12 startups are located in the state of Indiana:
  • Artistorm (West Lafayette), artwork distributor
  • Computing Universe (West Lafayette), computer service
  • Foresite (formerly Contamination Studies Laboratories, Inc.) Kokomo, testing and consulting laboratory
  • Cytometry for Life (West Lafayette), HIV testing
  • Darkstart Technologies (West Lafayette), testing equipment for data communication and computers
  • Griffin Analytical Technologies (purchased by ICx), West Lafayette, analytical instrumentation
  • Merlin's Magic Castle (West Lafayette), educational learning tool
  • Passageways (West Lafayette), web portal solutions for financial organizations
  • Quadraspec (West Lafayette), commercial physical research
  • Shoup's Country Foods (Frankfort), custom processing plant and retail meat store
  • TranCell Technologies (West Lafayette), sustainable energy solutions for the electronics market
  • Global Networked-Intelligence Contests (West Lafayette), turnkey software for digital information
• Passageways (competed in 2001) received seed capital from the Purdue Employees Federal Credit Union and was listed on the 2008 Inc Magazine's Top 500 Fastest Growing Privately Held Companies in America.
• Quadraspec (competed in 2005) employs 50 people in 2008.

Discovery Park began in 2001 with four virtual centers and a vision of a highly interdisciplinary matrix of faculty who would be encouraged to consider the entrepreneurial possibilities of their research. The inclusion of the Burton D. Morgan Center for Entrepreneurship as an initial center reflected the importance of entrepreneurship to the vision and mission of Discovery Park.

The creation, in 2005, of the Certificate in Entrepreneurship and Innovation Program for undergraduate students at Purdue made education and experience with entrepreneurial issues possible for students. This highly successful program has now enrolled over 1000 Purdue undergraduates.

Does the program make a difference in the education of Purdue students? We believe that it does. Here is one example of many.

Sawyer Sparks is an undergraduate student at Purdue University, majoring in agricultural economics. He is also enrolled in the Certificate in Entrepreneurship and Innovation Program. Sawyer has completed the initial six credit hours of the 15 hours required to attain the Certificate. He is currently enrolled in Entrepreneurship 490B, the capstone course.

Sawyer recently participated in the Elevator Pitch Competition, hosted by the Certificate Program and the Burton D. Morgan Center for Entrepreneurship. This competition places students and faculty in front of venture capitalists for 60 seconds. The task is to present a captivating and succinct description of one's business idea: a description that would lead the audience-if captured in an elevator or for a moment at a meeting-to invite more detailed information. Sawyer pitched a product he produces, Soy-Doh. Soy-Doh is a wheat-free modeling compound aimed at children with allergies. Hundreds of containers of Soy-Doh have already been sold to schools, daycares, and households, and plans are being made to distribute it to large retailers.

Besides Soy-Doh, Sawyers has two other companies: Greene BioFuels, which processes sunflower seeds into biodiesel fuel, and S&T Feeds, which utilizes the byproducts of his biofuel processing as a high protein feed supplement. The cost of his biodiesel fuel is competitive--$1 a gallon lower than alternative sources. All of Sawyer's products are produced and manufactured in Greene County, Indiana - hence the name BioGreene LLC for the parent company for his three businesses. His company's goal for the next year is to increase production of sunflowers from 500 acres to 1000 acres.

Sawyer is both a successful fledging entrepreneur and an undergraduate student at Purdue. He will continue in the Certificate in Entrepreneurship and Innovation Program and have opportunities to compete in more Elevator Pitch and Business Plan Competitions at Purdue. These opportunities extend his major in Agricultural Economics in concrete ways. His experiences will be shared with other Purdue undergraduates to encourage them to think in innovative ways about their future and the career paths it holds.

Purdue University faculty members are among the world's best, but their individual research programs and breakthroughs often were not integrated with other scientists and engineers across the campus.

The Birck Nanotechnology Center, which became fully operational in mid-2006, is a highly collaborative center today, with many center projects involving one or more other Discovery Park centers. Dr. Tim Sands, director of the Birck Nanotechnology Center, recognized the importance of measuring the growth of faculty collaboration. Using statistics provided by publication information from INDURE and Purdue's e-pubs community, a process has been designed to measure the growth of scholarly collaboration.

A preliminary study of the 46 resident faculty members in Birck revealed an increase in the number of collaborative efforts in the center's research strengths -- nanoelectronics and semiconductor devices, nanophotonics and optics, nanobiotechnology and nanomedicine, energy conversion and heat transfer, nanomaterials, nanofabrication and nanomanufacturing, MEMS/NEMS, and nanometrology.

• From 2005 to 2007, publications surged 26 percent to 191 from 151, while the number of joint publications increased more than doubled to 34 from 15. These figures reflect a significant jump in collaborative scholarship.
• Birck researchers also published 106 archival papers through the center's affiliation in 2007 compared with 64 in 2006.

The Ecological Sciences & Engineering Interdisciplinary Graduate Program (ESE IGP) was birthed out of a need to enhance recruiting in the environment-related areas across campus and provide an educational structure that produced broader thinking students across multiple disciplines in the context of environmental sustainability.

The ESE IGP, developed by a group of faculty from across campus, was approved in 2003 and launched in fall of 2005, which was facilitated by the newly launched Center for the Environment. The Ecological Sciences & Engineering Interdisciplinary Graduate Program (ESE-IGP) provides students with educational and research experiences that integrate engineering, science, policy, and life cycle thinking concepts to addressing sustainable solutions that cut across multiple disciplines. The ESE IGP partners with a variety of academic units that provide the discipline foundation under a set of complementary integrating themes. The ESE IGP also serves as a catalyst to promote collaborative inter-disciplinary environmental and ecological research among Purdue University faculty members.

• The ESE-IGP is transforming graduate education for many at Purdue. The ESE is facilitating the development of broader thinking students in the context of sustainability and resilience that cuts across multiple disciplines, and exposing them to a wide variety of environmental work at Purdue.
• The ESE-IGP is enhancing recruitment of top graduate students to Purdue in all environment-related areas at Purdue, which is benefiting multiple academic units. Faculty from 6 units within the Colleges of Agriculture, Engineering, and Science stated that the ESE IGP applicants had higher GPAs, GRE scores, and level of maturity than applicants through their traditional department portal in their area of interest.
• Applicants increased from 7 in 2007 to 38 for 2008 (70% accepted), to over 40 prospects as of October 1, 2008 for the 2009 academic year.
• Professional development through coursework and activities such as the ESE campus-wide symposium that attracted 175 students, faculty, and citizens last year to Purdue on the topic of sustainability.
• The overwhelmingly positive impact of the ESE IGP on graduate recruitment and education has resulted on financial support from the Deans of the Colleges of Agriculture, Engineering, Liberal Arts, Science, and Technology and the Provost Office for the 2008-2009 academic year.

Our Nation is faced with the educational problem of efficiently and rapidly increasing capacity in veterinary homeland security.

A web-based, graduate level, distance learning certificate program was developed for individuals involved in animal emergency response. Participants enhance their understanding of natural and intentional threats to animal health and strengthen their skills in management of animal-related emergencies. This activity is a cooperative effort among the Purdue University School of Veterinary Medicine, the Purdue Homeland Security Institute, the Indiana State Board of Animal Health, the Indiana State Police, the Purdue Graduate School, and Purdue University Continuing Education and Conferences.

• A critical mass of professionals are trained to prevent and respond to animal-related emergencies that have the potential to negatively impact the economy, food safety, public health, or animal health.
• More than 80 professionals from 27 states, Washington D.C., Singapore and Bermuda have enrolled in the veterinary homeland security program. Participants represent the veterinary profession, government, military, academia, law enforcement and industry. Completed projects included plans for addressing animal emergencies in various communities and the identification of community resources to be used in the event of emergencies involving animals.
• Ten new graduate courses are available on-line and the curriculum has been declared in compliance with the national Animal Health Emergency Management System (NAHEMS) Guidelines. The curriculum has been presented at several meetings, conferences and conventions. The Journal of Veterinary Medical Education also published an article about the program.

The problem of "brain drain" is a challenge facing Indiana as talented college graduates leave the state in search of high-paying, high-tech jobs in large metropolitan and/or coastal regions.

The Discovery Learning Research Center created the Interns for Indiana (IfI) program in 2004 through initial support from Lilly Endowment, Inc. The program goals are threefold: (1) offer students professional training through experiential learning, (2) introduce students to myriad occupational opportunities across the state, and (3) foster economic growth of local businesses through increased access to skilled labor. IfI focuses on key state needs to enhance the quality of Indiana's workforce by providing experiences that lead more of the highly qualified Purdue students to seek in-state employment after graduation. Keeping highly qualified and educated graduates in the state will drive driving economic development and job creation through the support of high-tech start-up companies. The program combines an internship in a start-up company with professional development seminars and participant analyses of their experiences. Students apply the diverse skills they learn in school while gaining professional experience, exposure to entrepreneurship, and familiarity with local high-tech employment opportunities.

• IfI has placed 374 students with 140 partner companies for more than 146,500 hours of labor.
• Nearly one in four companies has hired their intern for full-time employment after graduation.
• Over 70% of IfI alumni have remained in the state after graduation, compared to the overall Purdue retention rate of 56%.
• 80% of the interns respond that the program increased their interest in working for a start-up company while 62% developed an interest in starting their own companies.
• 96% of companies reported that the interns assisted in company growth.

Science, technology, entrepreneurship and innovation will play even greater economic development roles in the new global knowledge economy, especially in the life sciences and medicine. Applying powerful new nanotechnologies will revolutionize medical practice.

Discovery Park has developed a number of partnership agreements with educational institutions, corporations, and research agencies in Australia, China, India, South Korea, New Zealand, Singapore and Qatar.

One of the most significant partnerships is between Discovery Park and the Korean Institute of Science and Technology (KIST), in Seoul, South Korea. This "Korean MIT" has strengths in the discovery of biologically active novel compounds, drug-delivery systems, tissue engineering, validation of drug targets, and molecular imaging.

• A joint research proposal, "Molecular Imaging and Nanomedicine for Theragnosis Using Nano-Bio Material," was selected for the international Global Research Laboratory awards. KIST has committed additional funding to support GRL activities at Purdue including travel and expenses for KIST researchers working in Discovery Park. GRL funding will be leveraged with companion proposals to the National Science Foundation Office of International Science and Engineering program, "Partnership in Research and Innovation."
• Similar proposals will be submitted to the Fogarty International Center and to other divisions of National Institute of Health. Purdue is extending this life science partnership to other areas such as bioenergy.
• The Bindley Bioscience Center at Discovery Park, and the KIST Life Sciences Division, Biomedical Research Center, also have established collaborative projects in biomedical engineering, drug delivery technology, cytomics and molecular imaging. These programs emphasize education, training, technology transfer, teaching exchanges and joint proposal writing.

Economic development relies on new technology reaching the marketplace in a timely manner. Many researchers lack the expertise necessary to launch a start-up company and manufacture their innovative products.

Discovery Park's Center for Advanced Manufacturing requested funding proposals from faculty for interdisciplinary projects. One project investigated the production of nano-particulate metals using modulation-assisted machining (MAM) technology. The center provided $500,000 in funding and purchased equipment for it and 15 other projects. Purdue also raised the awareness of industry and government leaders regarding the projects. MAM generated strong interest because the technology can be applied to a variety of industries. It also can create an economical way to manufacture nano-particulate materials.

A start-up company called M4 Sciences was launched in the Purdue Research Park to commercialize the product and continue technology development. Company founder James Mann won Discovery Park's 2006 Entrepreneurship Business Plan competition in the graduate division and also benefited from an innovative Entrepreneurship Boot Camp sponsored by the Burton D. Morgan Center for Entrepreneurship. A proposal also has been submitted to the 21st Century Research and Technology Fund. The Center for Advanced Manufacturing continues to provide capital support to increase production.

A primary goal of Discovery Park is to transform a traditional academic culture into one that is more entrepreneurial and supportive of innovation. The Burton D. Morgan Center for Entrepreneurship helps achieve this in two ways -- first, through the delivery of entrepreneurship education programs to students and faculty, and second, by taking a more proactive approach to assessing the commercial viability of research occurring at Purdue. To transform the culture at such a large university, the undergraduate student population could not be ignored.

The Certificate in Entrepreneurship and Innovation Program was first offered to undergraduate students in Fall 2005. Like Discovery Park, it was designed to involve all ten academic colleges and be highly interdisciplinary and collaborative. Indeed, the behind-the-scenes work done to implement the Certificate Program has established stronger relationships with the colleges, has involved numerous faculty across the campus, and has created strong connections between students and Discovery Park.

• The Certificate in Entrepreneurship and Innovation Program is transforming undergraduate education for many at Purdue. Interest and enrollment from across the colleges has surpassed expectations. To date, over 1000 students have completed ENTR 200 Introduction to Entrepreneurship and Innovation.
• An annual Elevator Pitch Competition for students and Purdue Research Park entrepreneurs was an outgrowth of certificate program courses.
• Participating students have made a strong showing in entrepreneurial competitions at Purdue and across the state.
• A student organization called Purdue Innovations was founded by Certificate Program students.
• Exit surveys given at program completion indicate that:
  • 82% of students perceived their entrepreneurial ability to be above average or excellent
  • 85% agreed or strongly agreed that the Certificate Program improved their analytical, communication, and presentation skills
  • 91% agreed or strongly agreed that it improved their ability to evaluate ideas
  • 88% agreed or strongly agreed that it increased their confidence that they could be an entrepreneur
  • 23% reported that they are currently involved in a venture of some kind
  • 88% reported that they are likely or very likely to become involved in an entrepreneurial venture in the future.

Significant global demand exists for a noninvasive, accurate and reliable technology that would identify the biomarkers for early breast cancer detection in blood or other biofluids.

Dr. Daniel Raftery, Purdue chemistry professor and active member of the Bindley Bioscience, Cancer, Oncological Sciences and Energy centers in Discovery Park, wanted to take his promising research on using advanced analytical chemistry technology for breast cancer diagnosis from his laboratory to the marketplace. Raftery's technology builds on the strengths of two instrumentation developments:

• Mass spectrometry, which is highly sensitive for detection
• Nuclear magnetic resonance, which is highly reproducible

He combined the strengths of these two technologies and put together his Discovery Park research team, which included an expert on mass spectrometry who would complement his expertise on nuclear magnetic resonance. The result is technology that analyzes multiple small molecule metabolite biomarkers present in biofluids such as blood and urine that can detect cancers at an early stage.

• Raftery's research led to the 2007 launch of Matrix-Bio, Inc., an Indiana company developing early screening procedures to be used in doctors' offices in the next couple of years.
• The Office of Technology Commercialization and Discovery Park reviewed Raftery's first business plan in fall 2005 and offered strategic changes and also filed patents to protect the intellectual property. With a revised business plan, Matrix-Bio placed second in the 2007 Burton D. Morgan Entrepreneurial Business Plan Competition.
• Raftery also submitted an executive summary and investment presentation to Lonergan Partners in May 2007. MatrixBio was one of three companies selected to travel to Silicon Valley for presentations to potential investors. Raftery also attended a Discovery Park session on understanding and negotiating successful term sheets.
• In spring 2007, he participated in Burton D. Morgan Center's Elevator Pitch competition, which is designed to teach faculty and students how to convey succinctly and effectively the marketability of their product. Raftery won the competition.
• Raftery closed a seed round investment for Matrix-Bio in December 2007, and is in line to receive follow-on funding.
• Based on the progress at Discovery Park, Raftery's lab at Purdue has recently received major NIH funding for continued development of the technology that will be licensed to Matrix-Bio for future development.
• Through the continued support of Discovery Park and Purdue Research Park staff, management consultants and an attorney have been identified for MatrixBio. Additional funding has been secured for MatrixBio. Discovery Park and the Purdue Research Park will continue to work to ensure the company's success.

During the last few years, civilian and defense sectors have invested heavily in the development of micro-electro-mechanical systems (MEMS) for sensing, communications and other critical applications. MEMS combine electronic and mechanical components on a microscopic scale. Switches are needed to turn radio signals on and off for a variety of purposes, including the deployment and activation of weapons and routing satellite communications. However, MEMS have not thus far been able to meet stringent performance and reliability requirements. Reasons for unexpected failures are poorly understood.

The Prediction of Reliability, Integrity and Survivability of Microsystems (PRISM) Center was launched on April 15, 2008. The University of Illinois, Urbana-Champaign, and University of New Mexico will collaborate in PRISM. Purdue is one of 5 centers funded under NNSA's Predictive Science Academic Alliance Program (PSAAP); the other four are at California Institute of Technology, University of Michigan, Stanford University, and University of Texas at Austin. PRISM will be based at the Birck Nanotechnology Center and is affiliated with the Birck and Energy Centers, both in Purdue's Discovery Park.

About 35 researchers at Purdue, including faculty members, software professionals and students, will help perfect miniature switching devices for weapons systems and commercial applications by developing verified and validated advanced simulations needed to predict the reliability and durability of MEMS. A key aspect will be quantifying the uncertainties of both the validation data and the simulation and the impact of these on the accuracy of the reliability predictions. Dr. Jayathi Y. Murthy, professor of Mechanical Engineering, directs the new center.

"The center takes advantage of Purdue's interdisciplinary strengths and considerable expertise in computational modeling and nanotechnology," said Purdue President France A. Cordova. The devices are being created to replace conventional switches and other electronic components critical for radio communications and weapons deployment. MEMS are far lighter and smaller than conventional technology and could be manufactured in large quantities at low cost.

The new simulations will make it possible to accurately predict how well the MEMS devices would stand up to the rigors of battle and how long they would last in the field. Devices in missiles and other weapons must withstand crushing gravitational forces, temperature extremes and shocks from impact. In order for the predictions to contribute to decisions to deploy MEMS devices, the simulations themselves must be "reliable". Making such a determination requires that the simulations be verified and validated and that any uncertainties be quantified. Only then can the simulation be used to predict the reliability of a device with a quantifiable degree of certainty.

The research will draw on expertise and facilities affiliated with Purdue's Network for Computational Nanotechnology, based at the Birck Nanotechnology Center, and the Rosen Center for Advanced Computing, a division of Information Technology at Purdue. The NNSA national laboratories will be involved as unfunded collaborators and advisors in the research.

Healthcare providers rarely have the personnel or time to analyze issues and develop plans for improvement in short, defined timeframes.

Discovery Park's Regenstrief Center for Healthcare Engineering obtained the support of the Indiana Hospital Association and Purdue's Technical Assistance Program to create the Healthcare Technical Assistance Program (Healthcare TAP). The program links faculty and students from engineering, nursing, pharmacy, technology, communication and management to healthcare providers. The Purdue teams provide in-depth analysis on identified issues and make recommendations for short-term implementation. They also provide on-site performance improvement education based on lean manufacturing principles.

Since its inception, Healthcare TAP has served 33 Indiana hospitals and worked on 55 projects. It also has worked with the Indiana State Department of Health to analyze gaps in pandemic planning and implement quality improvement projects for local health departments.

• Example 1: A medium-sized hospital experienced significant delays transporting patients from the emergency department to other floors. Elapsed time periods ranged from 20 to 113 minutes. Healthcare TAP faculty and students from the College of Technology identified barriers to efficiency and worked with hospital staff to implement a "lean" healthcare program. Time between the emergency department to a floor for care decreased to an average of nine minutes.
• Example 2: A large hospital's clinical research revenue cycle routinely exceeded 45 days. The Purdue Healthcare TAP team from the Purdue school of Organizational Leadership and Supervision identified inefficient processes and helped the billing office implement a "lean" office program. The revenue cycle for the clinical research department was reduced by 33%.
• Example 3: A critical care hospital wanted to improve patient flow through the surgical process because 50% of all procedures began after the scheduled time. A Purdue team of nursing and industrial engineering faculty and graduate students analyzed surgical volumes, scheduling bottlenecks, staff availability and facility constraints. They made recommendations on schedule coordination, staff training and documentation. Implementation of these recommendations resulted in an improved rate of more than 75% on-time starts.

Nanotechnology as a tool for innovations is being researched world-wide. To drive more rapid innovation, scientists need to share information, modeling, simulations, and results during research projects so that research can be adapted and responsive to breakthroughs as they occur.

The Network for Computational Nanotechnology (NCN) mission is to support the National Nanotechnology Initiative (NNI) by designing, constructing, deploying, and operating www.nanoHUB.org, a national cyber-resource for nanotechnology theory, simulation, and education. The vision is to accelerate the transformation of nanoscience to nanotechnology and to build the nation's nanotechnology workforce. NCN was launched in 2002 with $10.5 million from the National Science Foundation and over $4 million in support from Purdue University. In 2007, NSF awarded NCN $18 million for a further five years of development and operation.

• NCN has deployed to date over 90 simulation tools and 1000 educational items authored by over 600 members of the nanotechnology community.
• From their web browser, researchers and students learn from nanoHUB educational materials, run state-of-the-art simulation tools, and view and interact with graphical results. In the 12 months ending June 30, 2009, more than 90,000 used nanoHUB. Over 400 research publications cite nanoHUB tools and/or resources.
• To date, nanoHUB resources have been used in 294 college courses taught at 92 institutions. There are nanoHUB users at 17% of all U.S. .edu institutions. www.nanoHUB.org is a powerful means for educating the U.S. nanotechnology workforce.

The United States is the undisputed world leader in developing revolutionary medical equipment and pharmaceuticals, yet healthcare process breakdowns cause more than 98,000 deaths and 1 million injuries each year. Total national health expenditures in 2005 exceeded $1.9 trillion, or 16% of the nation's gross domestic product, and the system is plagued with inefficiency, unnecessary redundancy, gaps in information flow, lack of patient engagement, misuse of resources and under-utilization of engineered models. Those barriers generate more than a $500 million of system waste per year.

With $3 million in initial funding from Regenstrief Foundation, the Regenstrief Center for Healthcare Engineering (RCHE) at Purdue's Discovery Park was established in February 2005 to catalyze the transformation of healthcare-delivery systems by applying the principles of engineering, management and science. RCHE established partnerships with the Indiana University School of Medicine, Ascension Health, and Indianapolis-based St. Vincent Health, to actively participate in research and serve as "living laboratories" for collaboration and testing of research outcomes.

• Center research has been conducted by 84 faculty research associates who represent a wide variety of healthcare research interests and expertise.
• $23.7 million has been generated in project funding and collaborative relationships have been formed with strategic partners (Ascension Health, St. Vincent Health, WellPoint Inc., and Community Health Network), project partners (Veterans Administration, Indiana University Medical Group, and Indiana University School of Medicine), and sponsors (Indiana Hospital Association, Indiana State Department of Health, Regenstrief Foundation and Regenstrief Institute).
• RCHE played a central role in creating the Healthcare Technical Assistance Program, which has generated $2.5 million in revenue since 2005. In fall 2007, the center officially established a research sub-center, the Center for Health Outcomes Research and Policy.
• RCHE has contributed to the establishment of the healthcare engineering signature area in the College of Engineering, healthcare systems concentration in the School of Biomedical Engineering, and Doctorate of Nursing Practice in the School of Nursing.
• RCHE is founding member of the Healthcare Engineering Alliance, a network of healthcare engineering researchers at the University of South Florida, University of Arkansas, North Carolina State University and North Carolina A&T State University.

The chasm between faculty research and cancer therapy must be bridged so that cancer patients can quickly benefit from the most up-to-date treatments.

The Oncological Sciences Center at Purdue's Discovery Park developed the Cancer Research Clinical Partnership. Its mission is to "get cutting-edge technology out of the laboratory and into doctors' offices." Laboratory scientists now involve clinicians in their research. Both parties benefit from ongoing communication.

Since June 2007, the partnership also has sponsored seven workshops that each attracted 20 to 40 Purdue faculty and medical professionals. A faculty member or clinician presented a current case or promising technology at each workshop, which was followed by an exchange of ideas.

• Dan Raftery, professor of chemistry, presented his research on identifying molecules that signal early breast cancer. His research, which has netted promising results, has led to the creation of MatrixBio. The company's goal is to develop early screening procedures to be used in doctors' offices in the next couple of years.
• The Horizon Oncology Center is participating in the first-ever human drug trials in Lafayette. The new drug used in the trials was developed by Endocyte, whose founder also serves as an executive committee member of the Oncological Sciences Center. The trials, developed in part through the Cancer Research Clinical Partnership, are focused on advanced lung and ovarian cancer with tumors that resist typical treatments. Trial participant Dave Williams of Petersburg expressed his appreciation to the Journal & Courier. "It's great that locals are working to speed up advancements in cancer treatment," Williams said.

The Bindley Bioscience Center (BBC) was one of the original four Discovery Park centers. Originally conceived of as a bioengineering center, it quickly evolved as a bioscience center, incorporating components of instrumentation and engineering together with life science applications. It was initially formed in early 2002, with V. Jo Davisson (Medicinal Chemistry) and George Wodicka (Biomedical Engineering) serving as interim co-directors. The space for the BBC was completed in August 2005, and faculty and staff moved into specifically designated interdisciplinary laboratories. The BBC has invested in more than $10 million in capital equipment, has helped recruit with $ or equipment in more than 10 faculty hires, and has 35 faculty engaged in projects funded through the BBC. The BBC has worked toward creating a new research environment to: (a) engage biosciences in a broader perspective; (b) utilize new and emerging technologies and to apply technologies in new areas; and (c) incorporate engineering principles for analysis and reverse engineering of biological systems. Collectively, the BBC is attempting to address major limitations of systems biology, especially those of measurement.

Analytical Proteomics Team (Clinical Proteomics Technology Assessment for Cancer biomarkers, CPTAC), F. Regnier, PI

• NIH/NCI , 9/01/06 - 8/31/11; ~$1.2M/year
• Cancer biomarker studies in consortium with 4 other national centers.

Ethanologenic Yeast Characterization, N. Ho, PI; Jiri Adamec, Bindley investigator

• Department of Energy, 10/01/07 - 9/30/10; ~$5M total
• Metabolomic analyses of yeast strains

Assembly of a Lignin Modification Toolbox, C. Chapple, PI; A. Friedman, co-PI

• Global Climate Energy Project, Stanford University, 6/1/08 - 5/31/11; $1.9M total for 3 years
• Generation of novel lignin modification enzymes and reagents

Clinical Translational Sciences Institute, C. Weaver, Purdue PI

• NIH, NCRR, 6/1/08 - 5/31/13 and ~25M$ (Total Purdue ~ 5 M$)
• Transformational approach to translational research in the institution and community (technology liaison position from Bindley- Charles Buck)

Global Research Laboratory, J. Leary and K.Park, co-PIs

• Korean Ministry of Science to Korean Institute of Science and Technology
• (KIST), 6/1/07-5/31/16; $4.5M (funding at KIST for collaborative research in DP)

Corporate partners in active research efforts: total = 17; Indiana companies = 11

• Intelimmune (Fort Wayne)
• Kylin Therapeutics (WLAF)
• Eli Lilly & Co. (Indy)
• Amgen (CA)
• TechShot (Greenville)
• LECO (St. Joseph, MI)
• Quadraspec (WLAF)
• Prosolia (Indy)
• Monarch (Indy)
• Neoclone (Madison)
• iCyt Visionary Bioscience (Champagne)
• MathSpec (Chicago)
• MatrixBio (WLAF)
• Cyntellect (San Jose)
• SnapFire (WLAF)
• Seyet (WLAF)
• Kymera (WLAF)

The near term goals of the BBC are to establish key areas of research that are recognized nationally. The membership is pursuing three central scientific themes in cancer biology, pathogens, and nutrition and diet. These scientific themes are supported by the underlying technical strengths of the Bindley in analytical instrumentation (a new center will start in July 2008), chemical and structural biology, tissue and cellular engineering, and the emerging area of nanomedicine. The BBC will work closely with other DP centers (e.g. Oncological Sciences, Cyber, Energy, Birck Nanotechnology) to assembly large multi-investigator proposals in these key research areas.

Birck Nanotechnology Center, established march, 2001. As one of the first academic nanotechnology research centers in the US, the Birck Nanotechnology Center provides solutions to challenges in healthcare, information access, energy, and the environment. In providing leading facilities and instrumentation for research at the nanoscale in a collaborative setting, the Center prepares the next generation of scientists and engineers to contribute to the formation of new industry in Indiana, the Midwest, and the nation, thereby strengthening the world's economy.

Construction of the Center facility began in June 2003, occupancy began in September 2005, and equipment installation was completed in December 2006. Dedicated on October 8, 2005, the following donors were in attendance: Mike and Kay Birck; Don and Carol Scifres, and Bill and Mary Jane Elmore, three couples who collectively contributed $42 million toward building construction.

• The $58M BNC facility is one of the largest and most comprehensive academic nanotechnology centers in the US; the 187,000 sq.ft. building includes a 25,000 sq. ft. cleanroom that is 45% Class 1, the first bio-pharma cleanroom integrated into a nanofab cleanroom, and 22,000 sq.ft. of specialized labs outside the cleanroom. The BNC was named "Facility of the Year" in 2007 by Controlled Environments Magazine.
• The BNC community includes over 160 Purdue faculty, 45 of whom have offices in the facility. 20 of the 30 resident faculty members who occupy primary offices in the BNC were recruited to Purdue since 2002. The BNC also houses ~220 graduate students from 12 academic disciplines, as well as ~30 support staff (business, clerical, and lab). All equipment in the facility is shared, and labs are designated by function rather than assigned to faculty.
• Major research centers during the early years of the BNC: NASA Institute for Nanoelectronics and Computing (INaC), closed Winter 2007; NSF Network for Computational Nanotechnology (NCN), renewed Fall 2007 (joint with Cyber Center); NIH Nanomedicine Development Center (lead transferred to U. Cincinnati in 2007).
• Research strengths (and self-assessment): nanoelectronics (top tier), nanophotonics (top tier), computational nanotechnology (top tier), MEMS/NEMS (probably top 15, and moving up), nano/bio (strong, but fragmented; recent faculty losses; great upside potential), nanomanufacturing, materials and metrology (broad strength, but lacking a national center), energy conversion (growing; would benefit from hiring at the senior level).

• New Centers Awarded: DOE/NNSA Center for Predictive Reliability, Integrity, and Survivability of Microsystems (PRISM), awarded Spring 2008 (joint with Energy Center); SRC NRI Midwest Institute for Nanoelectronics Discovery (MIND), awarded Spring 2008 (lead: Notre Dame).
• Peer-reviewed Publications were used as a metric to measure the impact of the investment in Nano at Purdue University: Among all US universities with established nano programs in 2002, Purdue has shown the greatest percentage increase in publication numbers from 2002 to 2007 (242%); during this period, Purdue has moved from 15th to 7th in "nano-" publications among all US universities; Joint publications among Center research groups increased by a factor of three between 2005 (virtual center) and 2007 (shared physical space).

• Aspiration: to be widely regarded as among the top three US academic nanotechnology research programs within the next five years, known particularly for translation of nanoscience and nanoengineering into nanotechnologies that address national and global challenges and opportunities.
• Opportunity: Integration of the theory and simulation researchers into or adjacent to the physical space of the BNC.
• Opportunity: Enhanced collaboration between scientists and engineers in the BNC, particularly at the frontier between nanotechnology and biology.

The Burton D. Morgan Center for Entrepreneurship is Purdue University's premier interdisciplinary hub for entrepreneurship. Through its initiatives of programs and competitions, the Center aims to stimulate entrepreneurship in the Purdue community and serve as a resource for the citizens of Indiana and beyond. Located in Purdue's Discovery Park, the Burton D. Morgan Center for Entrepreneurship plays a key role in facilitating business development for emerging concepts and technologies stemming from Discovery Park research. In 2007, the Burton Morgan Center became a part of the national Kauffman Campuses Initiative to expand its entrepreneurship learning programs across the Purdue campus into other disciplines.

Business Development & Intellectual Property Development creates and develops linkages between Discovery Park Centers and the Office of Technology Commercialization. A key objective is to accelerate research that will result in intellectual property. A Faculty Boot Camp is annually hosted during fall break with 70+ attendance normal. Sponsored by the Burton D. Morgan Center for Entrepreneurship, Purdue Research Foundation, and Lonergan Partners, the program educates faculty, staff, and student entrepreneurs about venture capital, other funding sources, company formation, the importance of human capital, selling your idea, sources of capital, and company valuation. Among the attendees, three Purdue startups - Moerae Matrix LLC; Kylin Therapeutics, Inc.; and Events 180° LLC were selected and mentored for a trip to Silicon Valley to meet with area investors.

Certificate in Entrepreneurship and Innovation inspires undergraduate students in all majors to be entrepreneurs and innovators. Through a series of five 3-credit courses and related experiential learning programs, students learn how to develop innovative ideas, write business plans, acquire funding, and start new business ventures. The knowledge and skills developed throughout the program will help students succeed in both business startup and corporate environments. Initiated in fall 2005, over 1000 students have enrolled in Certificate program curricula, with over 250 students enrolled for Fall 2008 across 10 sections. In fall 2008 a "Women and Leadership" course will be launched. Synergistic partnerships exist with the Entrepreneurial Learning Community, Interns for Indiana, and Discovery Park Research Internship. A global entrepreneurship study abroad program has been in place for the past two years: Korea (May 2007) and China (May 2008).

Entrepreneurial Leadership Academy is a program of the Kauffman Campus Initiative designed to foster understanding of entrepreneurship and technology realization among faculty and staff. Academy members are introduced to content and resources available at Purdue, state, national, and international levels. The goal to develop a campus community of leaders that support and study entrepreneurship and technology realization. 2007-2008 was the inaugural year for the Academy, which comprised 10 faculty across all Purdue schools and colleges. Each Entrepreneurial Leadership Academy faculty member is tasked with undertaking a high impact project that fosters campus entrepreneurship and entrepreneurial leadership.

Technology Realization Program introduces graduate students to the opportunities available through multidisciplinary entrepreneurship. Comprising seminar and workshop courses, graduate students across Purdue's Colleges and Schools are connected to jointly explore ways for bringing technologies to market. Beginning fall 2008, the Program connects the Krannert School of Management's MBA Technological Innovation and Entrepreneurship (TIE) Option with a university-wide curriculum on entrepreneurship through technology realization so that multidisciplinary teams of graduate students can be formed. The Program is open to all students across disciplines to expose as many graduate students as possible to entrepreneurship topics and skill sets. A part of the Technology Realization Program are students on assistantship working in the Technology Commercialization Laboratory, where high level assessments of business concepts and market opportunities are performed.

• The Burton D. Morgan Business Plan Competition aims to stimulate the entrepreneurial spirit on Purdue's University campus. Student teams participating in undergraduate and graduate divisions develop business ideas into a full business plan, culminating in formal business plan presentations in front of a panel of judges. Created in 1987, the Burton D. Morgan Business Plan Competition is the third-oldest business plan competition in the United States, and one of the most prestigious by offering $100,000 in total prize money.
• Elevator Pitch Competition has the goal of helping students to distill their business and new product ideas. An annual event held in conjunction with Purdue's Certificate in Entrepreneurship and Innovation Program, students compete for $1,000 in total prize money by providing a two minute synopsis of their idea to judges in a "walk-to-the-elevator" pitch scenario.
• Purdue Life Sciences Business Plan Competition is a bi-annual national competition held on Purdue's campus that highlights breakthrough life science technologies. Participants compete for total prize money amounting to $100,000 through a series of rigorous stages of executive summary and business plan submissions, culminating with a presentation by finalists to a panel of judges, including venture capitalists.
• Social Entrepreneurship Idea-to-Product Competition aims to provide a commercialization pathway for student-created products that that address social needs and are nonprofit in nature. The top three winners receive funding to travel to the national I2P Social Entrepreneurship Competition.

• To create an endowment for BDMCE initiatives
• To create an entrepreneurship community
• To facilitate open innovation between Purdue and the corporate community
• To become a leading, prominent, globally ranked entrepreneurship center

The formation of the Discovery Park's sixth center, the Center for Advanced Manufacturing (CAM), was announced by Purdue President Martin Jischke at the fourth annual Advancing Manufacturing Summit on May 18, 2004, with operations starting on July 1, 2004 under the leadership of John Sullivan, CAM's current Director. CAM has three full-time staff members: Rich Couch (Director of Engagement), Leza Dellinger (Administrative Assistant), and Steve Shade (Managing Director). The majority of CAM's research activities are conducted on its behalf in existing manufacturing-related centers and labs in the Colleges of Agriculture, Engineering, Science, and Technology. CAM currently has two affiliated sub-centers; the Center of Excellence for Product Lifecycle Management (PLM), and the Pharmaceutical Technology and Education Center (PTEC). PTEC is led by Rex Reklaitis (Director) and Prabir Basu (Managing Director).

CAM pursues research in all product and process manufacturing-related programs, but has focused efforts in three primary areas: 1) Product Lifecycle Management, 2) Pharmaceutical Manufacturing, and 3) Machining-related Technologies. The PLM CoE conducts industry-partner funded research with faculty and students in all Purdue colleges and holds semi-annual meetings to review research progress, provide student/industry networking opportunities, and develop future research paths. PTEC conducts research in the areas of process design, development & prediction of product performance, quality and safety from early parameters, Quality by Design, general process design tools that allow integrated design of processes, and issues with scale-up of batch processes. CAM also has close contact with machining-related technology research labs in Mechanical Engineering, Industrial Engineering, and several labs in the College of Technology. CAM is the coordinating center for Purdue's New Manufacturing Economy Initiative, a $1 million, 1-year seed-grant effort focusing on five manufacturing-related areas. This program has a goal of strengthening Purdue's competitive position for up to $3 million in state funding to continue and expand efforts in the five focus areas.

CAM has very active state- and national-level engagement efforts. At the state level CAM, in collaboration with Rolls-Royce, co-founded and leads the Indiana Advanced Aerospace Manufacturers Alliance (IAAMA). The IAAMA has over 60 manufacturers and meets semi-annually to hear from state and national aerospace manufacturers, NASA, and other agencies, develop business and research opportunities, and to raise awareness of Indiana's aerospace industry. CAM also hosts regional advancing manufacturing summits; CAM will host the fifth and sixth regional summits in Fort Wayne and Southwest Indiana in 2008. CAM held the seventh annual Advancing Manufacturing Summit on May 6th. This annual event draws more than 500 attendees to campus to hear presentations from national leaders such as Allan Hubbard, Al Frink, Eric Mittelstadt, Leo Reddy, John Engler, and others plus speak with students in the poster competition and gain in-depth knowledge in the afternoon parallel sessions. CAM holds memberships in the National Council for Advanced Manufacturing (NACFAM), and the Great Lakes Manufacturing Council.

CAM is a co-PI on a three-year, $1.8 million DOL grant, collaborating with Ivy Tech Community College (PI) by developing new advanced manufacturing courses able to be deployed in traditional classroom settings, onsite, or asynchronously via hand-held media players. The PLM CoE collaborates with faculty in the College of Technology in developing and offering distance-learning courses in digital manufacturing. These courses, currently offered only to The Boeing Company are expected to be expanded to additional companies in the coming semesters. CAM is also working with Engineering Professional Education to offer courses developed through its collaboration with MIT's Lean Advancement Initiative.

• Over $25M in extramural funding through proposals led by or affiliated with C4E since June 2005 including:
  • National Air Emissions Monitoring Study from EPA ($14.6M) is the largest comprehensive study on air emissions from animal feeding operations.
  • Over $1.2M in awards from USDA's Integrated Water Quality program is improving water quality through the use of best management practices for controlling polluted runoff.
  • EPA-funded Fate of Hormones in Tile-Drained Fields and Impact to Aquatic Organisms project ($700K) is providing insight into the potential risk of hormone contamination from manure fertilizer.
• Awarded ˜ $1M in seeding 27 research projects and 3 faculty start-up packages in COE, COS, and COA), which has currently led to over $19M in awards and over $35M in proposals.
• Launched the Ecological Sciences & Engineering Interdisciplinary Graduate Program (ESE IGP) and the Environmental Entrepreneurship Idea-to-Product (EE-I2P) competition. ESE IGP graduate student funding in multiple colleges included USDA National Needs M.S., and Purdue Lynn and Doctoral Diversity fellowships.
• Engaged ˜ 900 stakeholders through the 2006 Midwestern States Risk Assessment Symposium, International Workshop on Agricultural Air Quality, River Vision and the first annual environmental research symposium.

• The Center for Gene-Environment Interaction, the Clean Manufacturing Technology Institute, and the Purdue Interdisciplinary Center for Ecological Sustainability have joined C4E.
• Applicants to the ESE graduate program have significantly increased (from 7 in 2007 to 37 in 2008). The incoming 2008 class will be 15 students, up from 4 in 2007. The first annual student-organized ESE Symposium drew 175 participants and 43 research posters.
• Thirty students representing 13 departments and 6 colleges competed for $10,000 in total prize money in the 2nd annual Environmental Entrepreneurship Idea-to-Product competition.
• C4E's Living Laboratories on the Wabash (LLOW) is a key partner with the Wabash River Enhancement Corporation in developing the comprehensive strategic plan for the Wabash River and will receive a grant to develop a watershed management plan for Lafayette/West Lafayette.
• C4E is engaging Alaskan Native communities in STEM learning and environmental stewardship. Activities in the last year included faculty-led hands-on workshops in the villages and joint proposal development.
• The first Indiana Rivers Rally brought together 175 attendees from government, university, citizen, and non-profit groups and has lead to new state-wide water resource coordination efforts.
• A team of C4E faculty recently competed with the University of South Carolina in the full proposal round of NSF's Centers for the Environmental Implications of Nanotechnology program. Through an NSF grant, the team will host a national symposium on Nanotechnology and the Environment in August.
• C4E made progress establishing a partnership with the University of Tennessee and Oak Ridge National Laboratory related to sustainable energy. This has resulted in Purdue's inclusion in the U.S-China Workshop on Bioenergy Production and Sustainability.
• C4E, with Bindley, received seed funding to establish an international bio-repository to be the basis of major global discovery for environmental science and health.

• Greenweek, in September, will showcase our efforts with Energy Center and PCCRC in sustainable energy.
• A Discovery Lecture Series featuring high-profile speakers in natural resource conservation will highlight Purdue's strengths and energize faculty to participate in large-scale efforts.
• Expanding the ESE IGP, generating philanthropic contributions through species naming opportunities, and developing an industrial board to generate core funding and facilitate technology commercialization.
• Major proposals for the next 1-2 years: Megacities ERC resubmission ($18.5M), International Cooperative Biodiversity Group resubmission to NIH ($4M), STC in carbon management with Energy and PCCRC ($20M), Superfund Basic Research Program to NIH with IU School of Med ($10M), and DOE Genomes to Life ($10M).
• C4E is leading efforts to create a Living Laboratory for Science, Engineering, and the Environment that would serve as a state-of-the-art facility for research collections, education, and community engagement, while providing headquarters for C4E administration and its sub-centers.

Advancing computing research and enabling science and engineering through cyber infrastructure is the core mission and value of the Cyber Center. The Center is involved in many joint projects with other DP centers.

The Cyber Center in its 3rd year of operation has 31 full time staff, which includes 15 staff members from the NanoHub project.

The Center has submitted 11 successful proposals with total awards of $21,224,480. Its 2007/2008 research expenditure budget was $7,359,381. The Center has contributed to grants led by other centers totaling $5,375,691. The Center has pledged a large amount of its budget to cost sharing and sponsorship of individual faculty efforts. Four faculty fellows have been funded, one of whom has submitted a patent disclosure and is forming a start-up at the Purdue Research Park, all based on work supported by the Center. A cost share of $250,000 was made towards the successful NSF NanoHub award. The Center supported the E. Coli team both during the NIH proposal writing stage and after it was successfully awarded. Additionally, the Center has kept up its support with cost share commitment of $64,480. A cost share of $36,083 was also made to the PURVAC project. The Cyber Center cost shared the ITaP/CRI lead effort to obtain the SiCortex machine. The Computing Research Institute (CRI) held its second successful Purdue-Industry High Performance Computing Workshop on April 7-8, 2008.

• Network for Computational Nanotechnology (NCN) (www.NanoHub.org) Under the leadership of Prof. Mark Lundstrom and Prof. Gerhard Klimeck, the NanoHub is the state-of the-art virtual computing platform for several large-scale science projects at Purdue. It is indeed an enabler to many projects at Purdue. The NanoHub was recently awarded $18,241,66 by NSF. The NanoHub is an example of a successful middleware cyber infrastructure that allows scientists to focus on science instead of computing issues. By investing in NanoHub, Purdue has gained tremendous visibility amongst science and cyber infrastructure communities.
• Purdue Ionomics Information Management System (PiiMS) (www.theionome.org) Under the leadership of Prof. David Salt, Cyber Center staff developed the crown jewel of this project, an open source Portal that made it possible to expand the project to several plant, e.g., Rice (funded by a $5M NSF grant), Arabidopsis thaliana (funded by $379,228 NIH grant) and maize (funded by $1,447,166 NSF). A long-term objective of the PiiMS team is to make the portal a foundational tool for the plant community through the iPlant collaborative.
• E. Coli Community Resource (www.ecolihub.org) Under the leadership of Prof. Barry Wanner, the EcoliHub is fully operational and its funding has been extended by NIH, (more information). EcoliHub would not have been possible without the initial investments made by Cyber Center and the Departments of Computer Science (CS) and Biological Sciences. This project continues to enjoy research and development support from CS faculty (Prof. Walid Aref) and software engineers at the Center.
• Purdue University Regional Visual Analytics Center (PURVAC) (www.purvac.org) The PURVAC project is led by Prof. David Ebert. Dr. Mourad Ouzzani and Prof. Ahmed Elmagarmid serve as Co-PIs. The Cyber Center received supplemental funding from the Indiana State Department of Homeland Security to follow up with the project extensions. A primary extension was to establish data feeds from the Indiana Network of Patient Care with all ER visits in the 73 hospitals across Indiana and the Purdue Clinic (PUSH) to study different aspects of public health surveillance, data cleaning, and privacy preservation. The Cyber Center, along with the School of Electrical and Computer Engineering, is now planning a new, $18M Center of Excellence to be funded by DHS for 6 years.

Dr. Tanu Malik from the Cyber Center is supported at an 80% level contributing to the SciAEther project (http://www.sciaether.org) under the leadership of Prof. Jim Caruthers. Starting July 1, 2008, Dr. Mourad Ouzzani will work at an 80% level on the GlobalHub (http://www.globalhub.org) project, under the leadership of Prof. Dan Hirleman. Currently, two members of the Cyber Center work on the Cancer Care Engineering (CCE) project. This project was conceived in collaboration with Oncological Sciences Center, eEnterprise Center, Bindley Bioscience Center, and ITaP. The Cyber Center continues to contribute to the development of the Hestia project. A grant from the Showalter trust to both the PCCRC and Cyber Center is currently being used to hire a post doc fellow.

Advancing Research that Revolutionizes Learning Through externally funded research projects, innovative programs, and collaborative partnerships, the DLRC is addressing a fundamental global challenge: translational research in learning, especially in Science, Technology, Engineering, and Mathematics. Since its inception in 2003, the DLRC has focused on creating, developing, and nurturing interdisciplinary research contributing to:

• the science of learning;
• assessment and (re)design of innovative educational programs;
• the development, testing, and deployment of new interactive learning technologies; and
• the promotion of educational equity and enhanced diversity.

DLRC proposals and projects have involved:

• 176 faculty, 11Colleges, all DP centers, 59 Departments/units
• Over 115 Companies and 52 External collaborators
• Over 700 Student researchers and entrepreneurs

• Facilitated submission of 107 proposals for ~ $300 million.
• $30 million in sponsored funding, $11 million in endowments
• More than 20-fold return on investment in 5 years.

DLRC has contributed > $870,000 to support academic units, including:

• $100,000 startup contributions
• $150,000 cost share
• $500,000 seed grants

• Facilitated submission of 49 proposals worth $87 million.
• $5.26 million in new sponsored funding
• $7 million in sponsored funding in final negotiation (NSF)
• New Centers: Assessment Research Center, and Susan Butler Center for Leadership Excellence

New Building: A 90,000 square foot, state-of-the-art DLRC building is under construction, featuring:

• Cutting edge classrooms equipped for learning research
• Highly flexible science lab teaching research space
• Breakout spaces, learning commons and conference rooms
• Office and collaboration spaces for research groups

This unique facility provides Purdue researchers with novel opportunities to study learning and the science of learning.

Enhancing Diversity

• NSF LSAMP: Louis Stokes Alliance for Minority Participation - bridge, retention and support programs to double minority graduates in the STEM disciplines.
• NSF S-STEM: Recruiting and Retaining High Need, High Potential Students to Food, Environmental, Engineering, and Life Sciences - Agriculture and the business community partner to recruit, retain, and equip high need / high potential students using novel learning experiences.

Improving the Pipeline: K-12 Education

• Howard Hughes Medical Institute: Electronic Field Trips in Comparative Biology - assessing the effectiveness of electronic field trips to bring cutting edge science and scientists to rural middle school classrooms.
• NSF nCLT: Center for Learning and Teaching in Nanoscale Science and Engineering - developing and evaluating high school professional development programs to integrate nanotechnology into high school science curricula.

Improving Undergraduate Education

• NSF Undergraduate Research Center: Center for Authentic Science Practice in Education (CASPiE) - a multi-institutional collaborative examining new models for providing authentic research experiences in intro undergraduate chemistry labs.
• NSF CPATH: Extending a Bottom-Up Education Model to Support Concurrency from the First Year - examining an experiment to revitalize undergrad computer science and computer engineering education using parallel program design.
• Lilly Foundation: Interns for Indiana - Assessing the impact of a novel internship program with high tech start-up companies aimed at stemming the 'brain drain' of college graduates and enhancing economic development.

Developing New Teaching Technologies

• Introduction to Aerospace Design - engineering, technology and engineering education collaborating to design and research the effectiveness of an online, gaming-based course to teach fundamentals of design in an aeronautics course.

Discovery Park's Office of Engagement was created July 1, 2007. The staff includes two full-time FTE-an Associate Director and an Operations Manager-and a 2/3s support staff member. Next year the support staff member will be full-time. The Associate Director's appointment is shared and spans Discovery Park, the Purdue Research Parks, and the Office of Engagement. Thus, the intent of this role is to connect Discovery Park activities with the Purdue Research Parks and activities coordinated through the University's Office of Engagement.

Systematic Public Access to Discovery Park with a consistent message
Since July 2007, over 2800 individuals have visited Discovery Park-businesses and corporations, teachers, students, parents, alums, retirees, and community groups. The following tools have been created for these "tours": (a) A ten-minute professionally produced video; (b) A "script" with poster stops in both Birck and Bindley; (c) A talking points overview with optional powerpoint; (d) A site on the webpage with numerous supplemental materials to target the interests of specific groups; (e) Three training sessions for "tour guides" have been held yielding over 50 potential guides; (f) A brochure describing the facilities in Discovery Park. In addition, Discovery Park participated in the State Fair, Homecoming, and Springfest with a consistent message and theme reaching significant numbers of citizens.

Collaborative communication and integrated staff
Discovery Park engagement meetings are held bi-weekly and include the Communication/media person, the Development staff member, the Foundations staff member, the P-12 director, and the engagement staff in the Center for Advanced Manufacturing and the Center for the Environment. Additionally, the Communication staff from the Regenstrief Center for Healthcare Engineering, the Energy Center, the Birck Center, and the central DP staff meet regularly and have worked collaboratively on several projects. The Associate Director attends regular meetings with both the Purdue Research Park staff and with the Office of Engagement-Associate Deans and Engagement Council. The Associate Director led a group through Engagement to hold two workshops on the Scholarship of Engagement.

Base infrastructure has been created for quality use of facilities
This infrastructure includes staff roles, processes, coordination with other offices and staff, materials, and equipment.

Assessment of all activities
Better feedback forms will be implemented for the tours; however, all activities need better evaluation and assessment. The University will apply for the Carnegie Foundation's Community Engagement classification with leadership from Discovery Park.

Collaboration throughout Purdue University
Coordination of Discovery Park partnerships/activities with numerous Purdue staff in the engagement/research park/industrial relations/cooperative extension area. A retreat will be held on July 14th to facilitate coordination, communication, and project partnerships.

High visibility for Discovery Park targeted at faculty, staff, and students
Discovery Park's phenomenal growth is contingent upon positive attitudes and broad involvement of Purdue's faculty, staff, and students.

The e-Enterprise Center at Discovery Park (e-Center) was one of four original centers whose operations began in January 2002. The goal of the e-Center is to catalyze growth by using systems technology and engineering in the solution of grand societal challenges.

The e-Center's initial activity focused on developing large scale interdisciplinary and multiple discipline activity and practices of Discovery Park. The e-Center (a) defined the position and hired the first Managing Director, (b) developed the first seed grant program, and (c) organized a pipeline process for systematically seeding, nurturing, and executing large scale activities. e-Center representatives met with Deans and department heads, and conducted forums to identify key Purdue assets for new large scale activity. Externally, e-Center personnel met with Foundations, corporate contacts, and visited program officers to identify opportunities. These activities provided key input concerning investment decisions, including the following examples:

• Provided 20% of e-Center original Lilly Endowment funding for cost share for the Network for Computational Nanotechnology (NCN), which became a flagship project of the Birck Nanotechnology Center. For a several month period, 50% of the e-Center's Managing Director's time was spent helping to grow NCN.
• Defined and developed a portfolio of manufacturing and logistics projects and recruited Professor John Sullivan to help lead this portfolio. This ultimately contributed to the founding of the Center for Advanced Manufacturing (CAM).
• Played a key role in the development of the Pharmaceutical Technology and Education Center (PTEC), e-Center staff filled the original key roles. PTEC ultimately led to the National Institute for Pharmaceutical Technology and Education (NIPTE) and an NSF Engineering Research Center in Structured Organic Composites. PTEC was transferred to CAM after its formation.
• The e-Center Director, Dr. Joseph F. Pekny, starting in November 2003, organized the proposal effort that was funded by the Regenstrief Foundation to found the Regenstrief Center for Healthcare Engineering (RCHE). Dr. Pekny served as the Founding Director of RCHE from January 2005 to February 2006. During the original three year trial period, a majority of e-Center resources were used to grow RCHE. RCHE is now a permanent Discovery Park Center.
• Provided significant support in terms of development and research staff time and cost sharing ($359,459 with F&A) for the Center for Catalyst Design (CCD). Begun in 2003 with a $2.4M grant from the Department of Energy, CCD continues today with support from DOE and ExxonMobil.
• Working closely with the Oncological Science Center, the e-Center has helped to seed an activity in Cancer Care Engineering and helped to raise over $3.5 million in seed funds. This activity closely involves the Indiana University School of Medicine.
• The e-Center was heavily involved in NASA Specialized Center of Research and Training in Advanced Life Support (ALS NSCORT) from December 2002 through September 2006 for total funding of $6.77M.
• The Purdue Regional Visualization and Analytics Center (PURVAC) was established in January 2006 to assist National Visualization and Analytics Center (NVAC) and the U.S. Department of Homeland Security and is funded by DHS. PURVAC is also supported by both the e-Enterprise (providing over $69,000 in direct cost sharing in the form of managing director support) and Cyber Center of Purdue's Discovery Park and is closely collaborating with Purdue Homeland Security (PHSI) and Regenstrief Center for Healthcare Engineering (RCHE) efforts.
• Assumed administrative responsibility for Purdue Homeland Security Institute (PHSI) that brings Purdue resources to bear on improving U.S. homeland security. PHSI was established with funding of $750,000 from the VPR for three years.
• Providing managing director support for the Purdue Institute for Defense Innovation's (PIDI), whose mission is to greatly expand Purdue activity in the Department of Defense research

The e-Center is currently focused on the development of the Purdue Homeland Security Institute (PHSI), Center for Energy Systems and Policy (CESP), the Cancer Care Engineering Project (CCE), activity in Global Health, and a Veterans Health Administration Program to found Engineering Research Centers (VERCs) to closely integrate research, education, and practice.

• Since August 2005, the Energy Center (EC) has built an energy research community of 185 Purdue faculty representing 7 colleges and 30 departments. EC supports 10 research initiatives: Bioenergy; Clean Coal Technologies; Electrochemical; Global Partnerships; Hydrogen; Nuclear; Power Electronics; Social, Economic, Political Aspects of Energy; Solar; and Wind.
• To date, submitted proposals for external funding have totaled $75.4M; awards total $39.6M. EC also facilitated submission of the two largest grant proposals in Purdue's history, the $125M/5 year proposal for DOE's GTL Bioenergy Research Center and a $500M proposal for the BP plc Energy Biosciences Institute. Although not funded, the effort to produce the proposals and Purdue's extremely close finish served to inform Purdue faculty of the competitive field and the development activities needed on campus to ensure success in future competitions.
• Notable successful proposals resulted in awards of $17M (third largest award in Purdue history) from the US DOE Predictive Science Academic Alliance Program to Jayathi Murthy et al for MEMs device reliability simulation; $6.25M MURI award to Steve Heister et al for Gelled Hypergolic Propellant research; and $5M from USDOE to Nancy Ho for working with the ADM Corporation to deploy her yeast for cellulose to ethanol conversion.
• Seed grants to Purdue faculty since center launch total $802,500.
• Conventional energy sources and conservation are addressed in new centers launched with EC support, e.g., an NSF Engineering Research Center for efficient hydraulic power systems led by Monika Ivantisynova. EC serves as a portal for external constituents interested in energy research at Purdue and an internal convener of faculty groups, thereby ensuring connectivity among energy stakeholders.

• Over 80 faculty from colleges such as agriculture, science, engineering are actively working together on all phases of Bioenergy. These efforts are resulting in funded proposals and plans for new proposals such as a Bioenergy focused Energy Frontiers Research Center proposal.
• Coal research activities have been energized in partnership with the State of Indiana's Lt. Governor's office through the Indiana Center for Coal Technology Research. Through this effort and our Purdue Calumet faculty we have engaged Mittal Steel and other companies in Northwest Indiana.
• Social, economic, policy and political factors are important factors in seeking solutions to the global energy challenge. EC has brought together faculty in this area. $1.6M in direct funding has been received by this team since the Center's launch in August, 2005.
• Two companies have been launched: (1) a company based upon thin film PV technology, and (2) a company based upon novel water splitting technology for hydrogen production on demand.
• EC is forming collaborations with the Center for the Environment (C4E) and the Purdue Center for Climate Change Research (PCCRC).

• The EC will strategically organize large multidisciplinary campus communities in many broad aspects of energy. The communities will lead to new curricula in energy at all levels, new large size research proposals, multiple Indiana and global industrial and academic collaborations, distinguishing Purdue symposia, develop new laboratories across campus, recruit key individuals for the three vacant energy chair professorships and establish additional chairs, and contribute to the new green energy economy.
• We see tremendous growth opportunity in 4 major areas based upon the core strengths of our faculty and our assessment of key areas of need: (1) Energy Systems and Policy Analysis, (2) Hybrid Vehicle Systems, (3) Novel Propulsion Systems, and (4) Energy Education for K to Adult.

Goals

1. Make Purdue one of the preferred US institutions for research collaborations globally
2. Enhance and maintain the excellent research reputation and visibility that Purdue enjoys at all levels globally
3. Provide global experience for Purdue faculty, students and staff
4. Contribute to the economic development of Indiana, nation and beyond
5. Define the 21st Century Land Grant University

• Partnership with Korean Institute of Science and Technology has led to a $4.5 million funding in a nine year relationship
• Conducted and proposed seven successful international research symposiums with China, South Korea and India
• Conducted two successful entrepreneurship study abroad programs in China and South Korea
• A researcher and a graduate student from Birck Nanotechnology Center spent five months in Bangalore, India
• Formed and/or developing eleven educational and research partnerships globally
• Formed and/or developing ten corporate partnerships globally
• Launched an environmental assessment project in Azerbaijan
• Developed low cost CD4 technology for HIV/AIDS Detection
• Launched global nanoHub

• The EC will strategically organize large multidisciplinary campus communities in many broad aspects of energy. The communities will lead to new curricula in energy at all levels, new large size research proposals, multiple Indiana and global industrial and academic collaborations, distinguishing Purdue symposia, develop new laboratories across campus, recruit key individuals for the three vacant energy chair professorships and establish additional chairs, and contribute to the new green energy economy.
• We see tremendous growth opportunity in 4 major areas based upon the core strengths of our faculty and our assessment of key areas of need: (1) Energy Systems and Policy Analysis, (2) Hybrid Vehicle Systems, (3) Novel Propulsion Systems, and (4) Energy Education for K to Adult.

• Facilitate student recruitment (internship/employment) by global corporations
• Provide global experience to students (study abroad, advanced research, conferences/symposiums)
• Provide global experience to faculty (e.g. sabbaticals)
• Conduct joint research symposiums
• Conduct joint research projects
• Form global alliances (joint institutes and centers)
• Form research and educational partnerships
• Participate in international trade shows
• Conduct professional training programs
• Contribute to economic development by attracting and connecting businesses to Indiana
• Cultivate alumni relations overseas
• Work with funding agencies to support international activities

To seek new opportunities, forge new partnerships, and nurture new relationships to advance cancer research beyond the laboratory.

The Oncological Sciences Center (OSC) was established in July 2005 as the Discovery Park arm of the NCI-designated Purdue Cancer Center (PCC). The OSC capitalizes on the unique opportunities and synergies in Discovery Park to complement and leverage the outstanding basic cancer research that is the hallmark of the PCC. From its inception, a major goal of the OSC was to enable partnerships between Purdue engineers and oncologists/clinicians to advance cancer diagnosis and treatment.

• OSC Celebratory Symposium, August 16, 2005 "Progress and Problems in Cancer Detection and Treatment" - Oncologists from the Mayo Clinic (delegation lead by Frank Pendergast, MD, Director Mayo Cancer Center) and the Indiana University School of Medicine (delegation lead by Stephen Williams, MD, Director IU Simon Cancer Center (IUSCC) addressed an audience of Purdue engineers and scientists
• IU-PU-L (Indiana University-Purdue University-Lebanon) created, September, 2005 - Monthly meetings in Lebanon, IN (half way between Indianapolis and Purdue) initiated between oncologists at the IU Simon Cancer Center and engineers and scientists from Discovery Park

• Cancer Care Engineering
• Facilitated CPTAC (Bindley Bioscience)
• Facilitated recruitment of PCC Director

contributed more than $250K to major equipment purchases, supplied over $620K in seed grant funding, and supported 11 DURI students

Internal Partnerships

• e-Enterprise Center, DP
• Regenstrief Center for Healthcare Engineering, DP
• Bindley Bioscience Center, DP
• Discovery Learning Research Center, DP
• Cyber Center, DP
• Purdue Cancer Center (PCC)
• Network for Computational Nanotechnology
• Rosen Center for Advanced Computing
• College of Liberal Arts
  • Department of English
  • Patti & Rusty Rueff Dept of Visual and Performing Arts
• Purdue University Libraries

External Partnerships

• Indiana University Simon Cancer Center
• Roudebush Veterans Administration Medical Center
• Development (HSR&D) Center of Excellence in Implementing Evidence-based Practice
• Horizon Oncology Center
• Regenstrief Foundation
• Walther Cancer Institute Foundation

Membership

• 138 Members
• 9 Colleges/School
• 29 Departments

Cancer Care Engineering (CCE)

• Highly interdisciplinary(Eighty clinicians, scientists, engineers, statisticians, computer scientists, staff and others)
• Cancer continuum from prevention to care delivery
• Predictive mathematical models (statistical, population and agent-based)
• Molecular signatures for diagnosis and progression
• Seed Funding Received: $3.35M

Cancer Research Clinical Partnership Program (CRCP)

• Local clinicians/PU engineers and scientists
• Monthly workshops/case study discussions
• Collaborations

Cancer Culture and Community (CCC)

• Partnership with the College of Liberal Arts
• Local community participation
• 600 English, 100 Theater students
• Pulitzer Prize winning playwright

Expand CCE team to rural Indiana

Expand CCE team to additional institutions

Nationally funded center for Cancer Care Engineering

New initiatives to translate Purdue technology and science to cancer clinics

Create an endowment for the CCC Program

Create an endowment for the CRCP Program

Center Funding (2005-07)

	2005	2006	2007	Total
Income	$2.5 m	$3.75 m	$8.5 m	$14.75 m
Expense	$500 k	$750 k	$1 m	$2.25 m
Purdue Gain:				$12.5 m

Research

Eighty-two faculty research associates from 11 Purdue colleges have conducted center research. RCHE is a founding member of the Healthcare Engineering Alliance, a national network of healthcare engineering researchers at the University of South Florida (USF), University of Arkansas (UA), North Carolina State University (NCSU) and North Carolina A&T State University (NCAT).

Partnerships

External collaborative relationships have been established with:

• Ascension Health
• St. Vincent Health
• Community Health Network
• WellPoint Inc.
• IU School of Medicine
• IU Medical Group
• VA
• Regenstrief Institute
• Indiana State Dept of Health
• Indiana Hospital Association

To seek new opportunities, forge new partnerships, and nurture new relationships to advance cancer research beyond the laboratory.

Internal collaboration includes Cancer Care Engineering, e-Enterprise Center, Oncological Sciences Center and PURVAC.

Learning

RCHE has significantly contributed to the establishment of the healthcare engineering signature area in the College of Engineering, the healthcare systems concentration in the School of Biomedical Engineering, and the Doctorate of Nursing Practice in the School of Nursing.

Engagement

RCHE has played a central role in developing the Healthcare Technical Assistance Program, which has generated over $2.5 million in revenue since 2005.

RCHE Renewal

The Regenstrief Foundation, which helped found RCHE, renewed funding in the amount of $11 million over the next 5 ½ years (Jan 2008 - June 2013).

An additional grant provided $1.35 million to fund Cancer Care Engineering and $1.1 million for research to improve primary care access and chronic care management. This grant also included funds to improve database and computational services (July 2007 - June 2009).

Health Outcomes Research and Policy

The Center for Health Outcomes Research and Policy was established in Fall 2007 as an RCHE sub-center to conduct research on the effectiveness of treatment strategies and interventions to improve patient outcomes and optimize cost efficiency.

Center for Assistive Technologies

In late 2007, the Indiana Family and Social Services Administration, Division of Disabilities and Rehabilitation Services contributed $1.5 million to RCHE to create a Center for Assistive Technologies. The center is working to improve collaboration on assistive technology (AT) innovation, communication within the AT community, and AT evaluation.

Core Center Designation

In January 2008, RCHE became a core center within Discovery Park, supporting its own leadership and administrative staff and occupying twenty-five percent of the new Mann Hall.

National Partnerships

RCHE has developed new partnerships with the American College of Physicians (ACP) and VHA, Inc. to disseminate research findings on a national level. ACP is the nation's largest medical specialty society with 124,000 members in general internal medicine and related subspecialties. VHA is a healthcare provider alliance of more than 1,400 not-for-profit hospitals and 21,000+ non-acute care organizations nationwide.

Meeting the needs of Americans with chronic illness has been identified as a major challenge facing the current and future U.S. healthcare system. RCHE's research is increasingly focused on designing and evaluating alternative care models and processes that can provide optimal care for the growing chronic illness population.

RCHE is also working to expand its national influence by proposing innovative research, dissemination and funding partnerships with Veteran's Affairs, Mayo Clinic, the National Science Foundation and the National Institutes of Health.

Interdisciplinary research on the Purdue campus has increased substantially through Discovery Park. The 444 proposals submitted in fiscal year 2007-08 included 69 different collaborative areas within Purdue University; the 240 awards for that time period reflect 45 collaborative areas at Purdue University. These 45 areas encompass departments from all ten academic colleges/schools as well as several administrative areas like Information Technology and the Office of Engagement. Interdisciplinary collaboration is one of the hallmarks of Discovery Park.

Federal agencies and programs provide significant opportunities for large, interdisciplinary grants; hence, it is not a surprise that federal agencies are a big source of the funding for Discovery Park. Federal agencies and programs account for 51% of the sponsored funding for Discovery Park; state funding accounts for 21%.

In addition to the sponsored funding provided to Discovery Park from industrial sources--$8,004,069 for this time period, several Discovery Park Centers also developed important partnerships with corporations. These partnerships often led to sponsored funding for faculty research. For example, the Bindley Bioscience Center has 19 corporate partners. Their work with companies has led to five SBIR (Small Business Innovation Research), STTR (Small Business Technology Transfer), or 21st Century Awards. The Cyber Center held two industrial workshops in 2007-08 that were attended by 169 industrial participants. The Burton D. Morgan Center for Entrepreneurship includes partnerships with 45 companies whose active participation has resulted from either the Certificate in Entrepreneurship and Innovation Program or the Technology Realization Program.

Selected examples of funded proposal titles include:

• Social, Economic, and Political Aspects of US Ethanol Policy, Energy Center, $749,961, National Science Foundation
• Network for Computational Nanotechnology, Birck Nanotechnology Center, Cyber Center, $18,241,665, National Science Foundation
• Accelerating Nano-scale Transistor Innovation through Petascale Simulation, Birck Nanotechnology Center, Cyber Center, Network for Computational Nanotechnology, $1,599,205, National Science Foundation
• Advanced Methods in NMR-Based Metabolomics, Bindley Bioscience Center, $1,470,580, PHS-NIH NAT Inst. Ofc General Medical Sciences
• Spray & Combustion of Gelled Hypergolic Propellants, Energy Center, $6,250,000, Army Research Office
• PRISM: Center for Prediction of Reliability, Integrity and Survivablity of Microsystems, Energy Center, Birck Center for Nanotechnology, $17,000,000, US Dept. of Energy
• Indiana Center for Assistive Technology, Regenstrief Center for Healthcare Engineering, E-Enterprise Center, $1,486,346, Indiana Family and Social Services Administration
• Mapping the Condition of Diporeia Insights to Mechanisms of Designs, Center for the Environment, $569,513, Great Lakes Fishery Trust
• Electronic Field Trips in Comparative Biology, Discovery Learning Research Center, Bindley Bioscience Center, $749,754, Howard Hughes Medical Institute

Discovery Park was conceived to drive the delivery of discoveries to society. To facilitate the discovery, development, and delivery processes, Discovery Park has created a pipeline to move new technologies and new ideas from the laboratories to the Purdue Research Parks. This innovation pipeline provides staff support for faculty research to identify new markets and new funding sources. Discovery Park provides programs to assist faculty, staff, and students with a broader and deeper understanding of the unique complexities associated with a start-up company. The Burton D. Morgan Center for Entrepreneurship provides coursework and training for faculty, staff, and students interested in entrepreneurial issues.

The metrics for Discovery Park reflect facilitation of 31 completed disclosures with 4 licenses/ options. Discovery Park contributes significantly to Purdue University's accomplishments in technology commercialization.

Following are two examples of disclosures that grew out of research at Discovery Park. While both of these examples are in the biotechnology sphere, Discovery Park staff are working with faculty technologies in many areas. Discovery Park's contributions to the biosciences and biotechnology areas are worth noting, however.

GSIST and GILISA Labeling Strategy. Quantification of intracellular metabolites is seen as a key step in furthering the understanding of cellular carbon metabolism. Researchers at Purdue University have designed a new high throughput method to identify and quantify key intracellular carbon metabolites. Their new method utilizes Group Specific Internal Standard Technology (GSIST) and a Global Isotope-labeled Internal Standard Addition (GILISA) labeling strategy. Their GILISA labeling strategy utilizes unique internal standards, allowing for direct quantification of known metabolites and relative abundance of unknown metabolites. This technology allows researchers to separate, quantify, and identify all carbon metabolites in a single 30 min LC-MS run, including sugars with identical molecular weights, due to the labeling strategy. The precise quantification of the changes in metabolite concentrations is critical to systems biology, and holds the promise of identifying important relationships between these molecules, protein, and other gene products. A more complete understanding of these relationships may hold the key to unraveling complex disease states. Dr. Jiri Adamec, Assistant Professor with Purdue University's Bindley Bioscience Center, was the lead inventor on this technology, collaborating with Dr. Fred Reigner, Professor of Chemistry at Purdue University, and Dr. Wen-Chu Yang, a post-doctoral research assistant in the Department of Chemistry, Purdue University.

Biomarkers for Cancer Metastasis. Metastatic cancer occurs when cancer cells break away from the primary tumor and travel through the bloodstream or lymphatic system and form a new tumor elsewhere in the body. Researchers at Purdue University have developed a method utilizing proteomics to identify altered protein expression levels present in metastatic tumors, and not primary tumors. They are developing this technology to identify key biomarkers in metastatic tumors. This technology could be used as a noninvasive and inexpensive way for physicians to predict metastasis and plan treatments accordingly. The multi-disciplinary Purdue research team consisted of Dr. Sulma Mohammed, Associate Professor of Cancer Biology with Purdue University's School of Veterinary Medicine, collaborating with Catherine Riley, a graduate research assistant, Dr. Jiri Adamec, Assistant Professor with Purdue University's Bindley Bioscience Center, Elwood Walls, a Continuing Lecturer with Purdue's Department of Biological Sciences, Dr. Xiang Zhang, also with Bindley Bioscience Center, and Charles Buck, Director of Operations of Bindley Bioscience Center.

Discovery Park connects faculty researchers with the Office of Technology Commercialization. Discovery Park also facilitates the creation of start-up companies based upon the work of the Technology Commercialization staff. One of the "big"mission areas of Discovery Park is the creation of a campus culture that is entrepreneurial. Discovery Park, through the Burton D. Morgan Center for Entrepreneurship and the Discovery Learning Research Center, supports several programs targeted at students, staff, and faculty for a better appreciation of the commercializable aspects of their work. These programs provide the educational tools essential to be a successful entrepreneur. Opportunities to learn about the world of venture capital and to network in these circles are offered. Students participate in the Interns for Indiana program which places them in start-up companies. Over 1400 undergraduate students have enrolled in the Certificate in Entrepreneurship and Innovation Program. Graduate students participate in the Technology Realization Program. Faculty and staff participate in the Academic Bootcamp and the Entrepreneurial Leadership Academy. All of these programs are Discovery Park investments in transforming Purdue's culture.

The tangible outcomes of these investments are start-up companies. Since 2001, Discovery Park has facilitated the development of 29 start-up companies. Most of these companies are located at the Purdue Research Park, but not all. These companies span many business sectors. In 2007 (calendar year), Discovery Park facilitated the development of four start-up companies.

Four Start-up Companies Facilitated in 2007 by Discovery Park

• AlGalCo
• Cytometry for Life
• Moerae Matrix, Inc.
• National Institute of Pharmaceutical Technology

Profiles for these four companies are provided following.

AlGalCo has the exclusive license from Purdue University to commercialize a new technology in which hydrogen gas can be generated simply by adding water to a solid alloy comprised of 95% common aluminum. Hydrogen is considered by many to be the ideal solution to our energy needs. It burns cleanly in a standard gasoline or diesel engine as well as in a fuel cell. The problem with hydrogen is that storage and transportation must be under very high pressure; until now. AlGalCo's solid alloy is completely safe, inert, and can be stored indefinitely at regular atmospheric pressure. The aluminum used for the alloy can be standard industrial grade or scrap aluminum from old cars and recycled beverage cans. After reacting with water, the aluminum becomes alumina which can be sold into a very active market. The other 5% of the alloy is gallium which serves only as a catalyst and is not consumed in the reaction. The process has been established to easily and inexpensively recover the gallium and incorporate it an unlimited number of times into fresh alloy. The first application is a one kilowatt in-home, emergency portable generator for medically fragile customers living in rural areas. Since hydrogen burns cleanly, gensets can be placed directly where they are needed and all necessary medical devices operated for as long as the grid is down. The successful Phase II preproduction genset demonstration may be viewed: www.youtube.com, AlGalCo I, Phase II demo. A five kilowatt genset to power an entire home as well as a water purification application is also ready for commercialization.

Cytometry for Life, is a not-for-profit Foundation that strives to reduce the cost of medical diagnostics in resource-limited countries. The focus of the organization is the devastating problem of HIV/AIDS in Africa where nearly 70% of the population (those in rural areas) do not have access to CD4 diagnostics and therefore fail to qualify for life-saving therapeutic drugs. In conjunction with the Purdue University Cytometry Laboratories within the Bindley Bioscience Center in Discovery Park at Purdue University, a very low cost diagnostics instrument has been developed that can be operated in rural regions and does not require utilities or extensive laboratory resources. In partnership with Purdue, Cytometry for Life strives to bring low cost diagnostics in a way that is useful and effective to resource-limited regions of the world. www.cytometryforlife.org

Moerae Matrix is a development-stage biotechnology company focused on creating novel, locally-active peptide therapeutics -- drugs that mimic or block active portions of proteins naturally produced by the body to mediate key biologic functions. Four compounds, currently in the preclinical stage, have been generated to date from Moerae's discovery platform. These drugs will be developed for high-value market applications in general surgery, oncology, rheumatoid arthritis and wound healing. Current corporate resources (SBIR, matching state and angel funds) have been utilized to establish proof of concept in animal models (lead drug) or animal tissues. The Company seeks $1MM to accelerate work in support of IND submission for its lead drug in surgical scar and adhesion prevention. The therapeutic drug IP is all held through PRF.

National Institute for Pharmaceutical and Technology Education (NIPTE) is an independent, nonprofit organization representing 11 U.S. universities that are leaders in pharmaceutical science and engineering. In addition to Purdue, the other member universities are Duquesne University, Illinois Institute of Technology, Rutgers University, the University of Puerto Rico, the University of Connecticut, the University of Iowa, the University of Kansas, the University of Kentucky, the University of Maryland-Baltimore, and the University of Minnesota. The consortium was created specifically to work with the FDA and industry to enhance the way pharmaceutical products are being developed and manufactured by increasing the quality and education of best practices used.

Also in 2008, TrustBearer Labs began a new product, Identity Alliance, which had its roots in the Purdue Research Foundation's Office of Technology Commercialization and was facilitated by Discovery Park.

TrustBearer Labs is an authentication solutions provider with over 10 years experience developing products and custom software for trusted devices such as smart cards, biometrics, and USB tokens. Staff members include software engineers, project managers, and graphic/web designers with experience in all aspects of trusted device and security software development. TrustBearer Live, the company's flagship product, simplifies integration of trusted devices with web-based applications enabling instant deployment of online applications for trusted devices on a variety of platforms. TrustBearer Labs is located in downtown Fort Wayne, IN.

The first route for the delivery of new knowledge to society is through publications. Peer-reviewed publications contribute to faculty evaluations and university rankings. Peer-reviewed publications disseminate knowledge across the globe and become the foundation for the next generation of scholars. Discovery Park expands the publications of Purdue's faculty and students through cutting edge facilities, through the integrated, interdisciplinary teams that are the core of Discovery Park, and through administrative support for these teams. Discovery Park has expanded the research capabilities of Purdue and the delivery of knowledge from Purdue to the world. The peer-reviewed scholarship published by faculty affiliated with one of the Discovery Park Centers is making a mark: the identification of 703 peer reviewed publications by faculty affiliated with Discovery Park for the 2007 calendar year is a significant number.

In addition to this measurement of scholarship, other markers of knowledge delivery are important. The Cyber Center has contributed to the development of eleven new software systems. Both the Regenstrief Center for Healthcare Engineering and the Center for the Environment identified Ph.D. and Master's theses related to research facilitated or funded through their centers: Six for Regenstrief and five for the Center for the Environment.

Rather than the provision of a sampling of the scholarship across Discovery Park, this report highlights a publication from the Birck Nanotechnology Center which reflects a core value of Discovery Park-collaborative scholarship. Collaboration among faculty who conduct research in the Birck Center has risen dramatically. From 2005 to 2007, publications surged 26 percent to 191 from 151, while the number of joint publications more than doubled to 34 from 15. These figures reflect a significant jump in collaborative scholarship. Following is an example of this synergy from the Birck Nanotechnology Center:

• R. R. Lahiji, B. D. Dolash, D. E. Bergstrom, R. Reifenberger. 2007. Oligodeoxyribonucleotide Association with Single-Walled Carbon Nanotubes Studied by SPM. Small 11, 1912-1920.

Other examples of collaborative scholarship:

• Huff, T. B.; Hansen, M. H.; Tong, L.; Zhao, Y.; Wang, H.; Zweifel, D. A.; Cheng, J.-X.; Wei, A. (2007). Plasmon-resonant nanorods for two-photon luminescent imaging and photothermal therapy, Proc. SPIE 6448, 11. Oncological Sciences Center, Chemistry and Biomedical Engineering
• Liu, J., L.S. Lee, L.F. Nies, C.H. Nakatsu and R.F. Turco. 2007. Biotransformation of 8:2 Fluorotelomer Alcohol in Soil and by Soil Bacteria Isolates, Environ. Sci. Technol. 41(23): 8024-8030. Research collaboration in microbiology, soil chemistry, and environmental engineering.
• Rakesh Agrawal, Navneet R. Singh, Fabio H. Ribeiro, W. Nicholas Delgass. Sustainable fuel for the transportation sector. Proceedings of National Academy of Sciences, approved February 5, 2007. Energy Center.
• Y. Zhao, J. C. Fleet, J. Adamec, D. E. Terry, X. Zhang, S. Kemeh, V. J. Davisson, C. M. Weaver. Effects of hindlimb unloading and bisphosphonates on the serum proteome of rats. Bone, Vol. 41 - Issue 4, pages 646-58. Bindley Bioscience Center, Foods and Nutrition, and Medicinal Chemistry and Molecular Pharmacology.

The transfer of knowledge and skills to Purdue students is an important facet of Discovery Park's capabilities. Discovery Park links faculty from every Purdue discipline in collaborative projects, and these projects involve and educate numerous graduate students. These collaborative, interdisciplinary teams expand the educational experiences of Purdue's graduate students and better prepare them for the faculty and research roles they will soon assume. The Bindley Bioscience Center housed 93 graduate students and the Birck Nanotechnology Center housed 188 graduate students in 2007-2008. Many more graduate students work from offices and labs around the campus on integrated, interdisciplinary Discovery Park projects. Following are samples of graduate student projects:

• Ruchith Fernando, Department of Computer Sciences - "Design and Development of a cceHUB Data Framework to Support the Uploading and Exploration of OMIC Data,"Oncological Sciences Center
• Daniel Fagerman, Civil Engineering - "In-situ Nitrogen and Phosphorus Sensing Using Diode Laser Raman Spectroscopy,"Center for the Environment
• Jessica O'Leary, Charles Jischke, Jon Gortat, Mary Ann Albrecht, Clayton Stobbs, and Susan Campbell, all MBA students, "SynergisT: Product Development Recommendations," Burton D. Morgan Center for Entrepreneurship, project in collaboration with Dr. James Morre, Department of Medicinal Chemistry
• Xiaojun Chen, Educational Technology - "Evaluating Knowledge Transfer within VHA's Clinical Improvement Services,"Regenstrief Center for Healthcare Engineering
• Alan Brockman, Mechanical Engineering - "Biological Hydrogen Production and Chemical Hydrogen Storage,"Department of Energy's National Renewable Energy Laboratory, Energy Center
• Dinelia Rivera-Burgos, Chemistry - "Evaluation of Immunoaffinity Capture Based LC/LC-MS/MS Platforms,"project in collaboration with Dr. Fred Regnier, Chemistry, funded by National Cancer Institute grant, Bindley Bioscience Center

Enhancing learning for Purdue's undergraduate students is also a key mission of Discovery Park. In addition to the development of new curricula and courses (reflected in the Launching Tomorrow's Leaders metrics), Discovery Park consciously designs and supports programs to involve undergraduate students in the interdisciplinary research projects of Discovery Park faculty. The Discovery Undergraduate Research Internship (DURI) Program, administered through the Discovery Learning Research Center, is the centerpiece for undergraduate research. The DURI Program placed 102 students on interdisciplinary Discovery Park teams in the 2007-2008 fiscal year. Several Discovery Park centers include additional undergraduate students on faculty or center projects.

• Mohd Rahmad, Electrical and Computer Engineering - "Building cceHUB Tools from Statistical and Population-based Research Codes for Cancer Care Engineering,"Oncological Sciences Center
• Kelly Collins, Elementary Education, College of Education - "The National Science Digital Library (NSDL) Video and Image Data Access (VIDA) Project,"Discovery Learning Research Center and Center for the Authentic Practice of Science in Education
• Shelby Koonce, Pharmacy - "Low birth weight and drinking water quality: a spatial epidemiological investigation,"Center for the Environment
• Jillian Jwienat, Health Sciences and Lindsey Morgenson, Pharmaceutical Sciences - "Rural Health Planning and Community Development in Kewanna,"Regenstrief Center for Healthcare Engineering
• John Farris, Chemical Engineering - "Splitting water with Al-Ga Alloys,"Energy Center
• Sheryl Woods, Biological Sciences - Ongoing project to discover microbial secondary metabolites that modulate intracellular pathways and possess drug-like properties, Bindley Bioscience Center

Additionally, the Oncological Sciences Center supports the Cancer, Culture, and Community Program which connected 95 undergraduate students directly with the featured writer/artist brought to campus.

The facilities afforded through Discovery Park to support research and new discoveries make a critical difference for faculty, staff, and students. In addition to the over $100 million in buildings at Discovery Park, the tools and equipment added contribute significantly to Purdue's research agenda. Since all of the equipment in Discovery Park is shared, the resources here are leveraged far more broadly than is typical when discussing laboratory space and equipment. Additionally, Discovery Park provides technical staff to support complicated and sensitive instruments and manage data.

In 2007, Discovery Park added $1.4 million worth of equipment to the Purdue University campus, much of it in Discovery Park. Since the inception of Discovery Park in 2001, Discovery Park has added $27 million worth of tools and equipment to our campus. Some of the most notable equipment includes:

High throughput genetic analysis
Discovery Park has contributed to next generation sequence analysis platforms now on campus. The SOLiD and 454 next gen sequencers provide capabilities for describing the genome sequence of new species and of genetic modifications created in the laboratory and in nature. As a compliment to these systems for determination of DNA sequencing, specific variations can be interrogated quickly, cheaply and in parallel with the GeXP analysis system in the Bindley Center. This system is an integrated platform for simultaneous detection of multiple genes or gene variants from many different samples. In the same experiment, the system can analyze DNA sequence, DNA modifications such as mutations and single nucleotide polymorphisms as well as mRNA expression.

Applications include: (a) Detect and describe distinct species in populations of soil and water bacterial populations, (b) Characterize genetic differences in cancer cell lines exposed to anti-cancer drugs, and (c) Characterize expression of neurotransmitter receptor gene sequences in cells that model nervous system communication. The users for these two pieces of equipment are interdisciplinary. The SOLiD system is especially important to researchers across the campus. Discovery Park, often, is a contributing investor to enhance the purchase of equipment by Purdue. For example, the GeXP system was purchased through a vendor award to Bindley Bioscience of $65K plus cost shares with Bindley Bioscience Center, the Oncological Sciences Center, and the Purdue Cancer Center to reach the total of $130K.

Complimentary tools for metabolomics
Characterization of the presence and quantity of small molecule metabolites in complex biological samples is the specialty of the Bindley Metabolite Profiling Facility (MPF). A suite of mass spectrometers specialized for different aspects of small molecule detection have been obtained in cooperation with investigators across campus. Lilly Endowment award funds augmented an NSF major research instrumentation award to enable the MPF to obtain multiple high sensitivity metabolomics instruments and a data handling and storage system to ensure data archiving. Two triple quadrupole mass spectrometers for ultra-high sensitivity analysis of specific metabolites in the sample were obtained in 2008 via consortium funding from 4 Purdue Colleges and the Provost's office. The new triple quads provide direct connection of data between existing metabolomics platforms (time of flight and ion trap mass spectrometers) via the integrated nanochromatography 'chip cube' system that was first available for complex biological sample analysis in the Bindley center.

Applications include: (a) Detect trace concentrations of vitamin D and its analogs in human samples, (b) Define metabolites associated with muscle wasting (cachexia) in cancer patients, (c) Identify active therapeutic molecules in medicinal herbs, tea and fungi, and (d) Precisely define concentration of specific cancer biomarker proteins. MPF users are campus wide, especially Science, Engineering, Pharmacy, Agriculture, Consumer and Family Sciences, Liberal Arts. The purchase of the triple quadrupole mass spectrometers reflects the collaborative leveraging of Discovery Park. The equipment was purchased via the Provost equipment matching funds in 2008 with contributions from Bindley Bioscience Center, and the Colleges of Pharmacy, Science, Agriculture and Consumer and Family Sciences (Lead unit for Provost equipment RFA) to reach the total cost of $400K.

• 4 start-up companies
• 31 disclosures were completed with 4 licenses/options
• 80 industrial proposals for $8,004,069 were awarded to faculty projects associated with Discovery Park with 56 industrial sponsors
• $3,717,876.77 total patent costs with 63.5% reimbursed by licenses
• 2 new graduate programs were launched
  • Graduate Certificate Program in Veterinary Homeland Security
  • Ecological Sciences and Engineering Interdisciplinary Graduate Program
• 20 new courses affiliated with Discovery Park that apply to degrees were taught; 4 new professional education courses were developed
• 9 teams affiliated with Discovery Park competed in one of the Discovery Park Business Plan competitions
• $1,383,927 was spent to improve facilities and equipment for the Purdue University campus
• $695,000 was awarded for seed funding through Discovery Park Centers
• 6 new faculty hires were facilitated by Discovery Park through start-up funding and office and lab space
• 5 new research centers/capabilities were developed

Discovery Park connects faculty researchers with the Office of Technology Commercialization. Discovery Park also facilitates the creation of start-up companies based upon the work of the Office of Technology Commercialization staff. One of the "big" mission areas of Discovery Park is the creation of a campus culture that is entrepreneurial. Discovery Park, through the Burton D. Morgan Center for Entrepeneurship and the Discovery Learning Research Center, supports several programs targeted at students, staff, and faculty for a better appreciation of the commercializable aspects of their work. These programs provide the educational tools essential to be a successful entrepreneur. Opportunities to learn about the world of venture capital and to network in these circles are offered. Students participate in the Interns for Indiana program which places them in start-up companies. Over 1000 undergraduate students have enrolled in the Certificate in Entrepreneurship and Innovation Program. Graduate students participate in the Technology Realization Program. Faculty and staff participate in the Academic Bootcamp and the Entrepeneurial Leadership Academy. All of these programs are Discovery Park investments in transforming Purdue's culture.

The tangible outcomes of these investments are start-up companies. Since 2001, Discovery Park has facilitated the development of 29 start-up companies. Most of these companies are located at the Purdue Research Park, but not all. These companies span many business sectors. In 2007 (calendar year), Discovery Park facilitated the development of four start-up companies.

Four Start-up Companies Facilitated in 2007 by Discovery Park

• AlGalCo
• Moerae Matrix, Inc.
• National Institute of Pharmaceutical Technology
• Intelimmune LLC

Profiles for these four companies are provided following.

AlGalCo has the exclusive license from Purdue University to commercialize a new technology in which hydrogen gas can be generated simply by adding water to a solid alloy comprised of 95% common aluminum. Hydrogen is considered by many to be the ideal solution to our energy needs. It burns cleanly in a standard gasoline or diesel engine as well as in a fuel cell. The problem with hydrogen is that storage and transportation must be under very high pressure; until now. AlGalCo's solid alloy is completely safe, inert, and can be stored indefinitely at regular atmospheric pressure. The aluminum used for the alloy can be standard industrial grade or scrap aluminum from old cars and recycled beverage cans. After reacting with water, the aluminum becomes alumina which can be sold into a very active market. The other 5% of the alloy is gallium which serves only as a catalyst and is not consumed in the reaction. The process has been established to easily and inexpensively recover the gallium and incorporate it an unlimited number of times into fresh alloy. The first application is a one kilowatt in-home, emergency portable generator for medically fragile customers living in rural areas. Since hydrogen burns cleanly, gensets can be placed directly where they are needed and all necessary medical devices operated for as long as the grid is down. The successful Phase II preproduction genset demonstration may be viewed: www.youtube.com, AlGalCo I, Phase II demo. A five kilowatt genset to power an entire home as well as a water purification application is also ready for commercialization.

Moerae Matrix is a development-stage biotechnology company focused on creating novel, locally-active peptide therapeutics -- drugs that mimic or block active portions of proteins naturally produced by the body to mediate key biologic functions. Four compounds, currently in the preclinical stage, have been generated to date from Moerae's discovery platform. These drugs will be developed for high-value market applications in general surgery, oncology, rheumatoid arthritis and wound healing. Current corporate resources (SBIR, matching state and angel funds) have been utilized to establish proof of concept in animal models (lead drug) or animal tissues.

National Institute for Pharmaceutical and Technology Education (NIPTE) is an independent, nonprofit organization representing 11 U.S. universities that are leaders in pharmaceutical science and engineering. In addition to Purdue, the other member universities are Duquesne University, Illinois Institute of Technology, Rutgers University, the University of Puerto Rico, the University of Connecticut, the University of Iowa, the University of Kansas, the University of Kentucky, the University of Maryland-Baltimore, and the University of Minnesota. The consortium was created specifically to work with the FDA and industry to enhance the way pharmaceutical products are being developed and manufactured by increasing the quality and education of best practices used.

Intelimmune LLC is a joint effort between a northern Indiana biotechnology firm and two Purdue University researchers. Intelimmune recognizes the importance of simple reliable tools with which to detect, characterize and quantify specific biomarkers significant to research and clinical diagnostics. Their mission is to apply a doctrine of innovation and simplification as a means to develop sophisticated analytical techniques and products that afford the researcher or clinician a high degree of confidence in their analytical results and facilitate solution of the larger problem. Their mission is achieved in an economically and socially responsible manner that allows customers, employees and community to consider Intelimmune as a trusted partner.

Also in 2008, TrustBearer Labs began a new product, Identity Alliance, which had its roots in the Purdue Research Foundation's Office of Technology Commercialization and was facilitated by Discovery Park.

TrustBearer Labs is an authentication solutions provider with over 10 years experience developing products and custom software for trusted devices such as smart cards, biometrics, and USB tokens. Staff members include software engineers, project managers, and graphic/web designers with experience in all aspects of trusted device and security software development. TrustBearer Live, the company's flagship product, simplifies integration of trusted devices with web-based applications enabling instant deployment of online applications for trusted devices on a variety of platforms. TrustBearer Labs is located in downtown Fort Wayne, IN.

Title	Date
CCD E-Lab Notebook, Including User Database, IP Digital Signature and Notarization	7/24/2007
Method for generating Hydrogen from Ammonia Borane	8/7/2007
Improved Endothelial Cell Responses on Patterned Titanium Surfaces with Rationally-Designed, Micrometer to Nanometer Features	8/17/2007
Atomic-Layer-Deposited Nanostructures for Graphene-based Nano-electronics	9/5/2007
Targeting Resequencing Using Massively Parallel (TRUMP) Methods for Mutation Detection	9/10/2007
Visual Analytic Tool for Liquid-Chromatography/Mass Spectrometry (LC/MS) Data Analysis and Interpretation	9/12/2007
Label Free DNA Detection Using Electrical Measurements	9/17/2007
Self-supporting Nanowire Array for High Perfomance Thermoelectric Power Generators	9/18/2007
Integration of Bulk Thermoelectric Materials with Carbon Nanotube Arrays by a Cost Effective Process to Obtain Thermomechanically Compliant and High Electrical Contact Conductance Contacts	10/18/2007
Holography Enabled Multi-Scale Optoelectronic Platform for Particle Manipulation	10/22/2007
Electrical Noise Thermometer Using Nanowires or Nanotubes	10/22/2007
RF Graphene Field Effect Transistor	11/7/2007
Graphene/Semiconductor Heterostructures and Heterojunction Devices	11/8/2007
Titanium Microneedle Devices for IntraocularDrug Delivery	11/20/2007
PHSI Software and Materials	12/5/2007
Group Specific Internal Standard Technology (GSIST) and Global Isotope-Labeled Internal Standard Addition (GILISA) Labeling Strategy	12/6/2007
Biomarkers for Cancer Metastasis  12/19/2007
Stippling by Example	2/12/2008
Synthesis of Graphene on Silicon	2/25/2008
Fabrication of Graphene Field Effect Transistors on Silicon Carbide Wafers using Chemical Vapor Deposition	2/25/2008
Apparatus and Method of Forming Metal Oxide Semiconductor Field-Effect Transistor with Atomic Layer Deposited Gate Dielectric	2/27/2008
Formation of Epitaxial Graphene in a Controlled Ambient	3/5/2008
Graphene on Atomically-Smooth Silicon Carbide	3/5/2008
Software for Building Mathematical Models from Experimental Data with a Bayesian Approach	3/6/2008
Electrokinetic Particle Capture and Patterning with Opto-Electrothermal Fluid Flow	3/7/2008
Method Silicon Substrate for Indium Gallium Nitride Light Emitting Diodes	3/25/2008
Flexible Neural Probe for Magnetic Insertion	3/31/2008
Scoops: An Edible Soy Based Ice Cream Waffle Bowl	5/5/2008
A Novel and Simple Cell-Based Detection System with a Collagen-Encapsulated B-Lymphocyte Cell Line as a Biosensor for Rapid Detection of Pathogens and Toxins	5/2/2008
Encapsulation of Living Cells Within an Aerosolized Sol-Gel Matrix	5/15/2008
Open Configuration Optoelectrowetting Droplet Acutation	5/28/2008

Mapping the condition of Diporeia: Insights to mechanisms of declines.
Funded by Great Lakes Fishery Trust, $596,513
Center for the Environment
PIs: Maria Sepúlveda and Tomas Höök (Purdue University); Co-PIs: Thomas Nalepa (NOAA-GLERL), David Fanslow (NOAA-GLERL), Jiri Adamec (Purdue U.), Jacques Rinchard (USGS-GLSC and U. Michigan), Krista Nichols (Purdue U.), Wendylee Stott (USGS-GLSC and U. Michigan), Steven Pothoven (NOAA-GLERL), Tom Johengen (U. Michigan), David Jude (U. Michigan), and Michael Wiley (U. Michigan).
Diporeia, a group of small invertebrate species, have historically been an important member of benthic communities throughout the Great Lakes.  These shrimplike creatures have served as sources of food for many economically important fish and their disappearance is negatively impacting the multi-billion dollar sport fishing industry.  Since the early 1990’s, Diporeia have experienced a precipitous decline in abundance in lakes Michigan, Huron, Erie and Ontario.  While many believe that the declines in Diporeia are linked to increases in invasive mussel species, this does not appear to be the sole factor determining their decline.  Interestingly, Diporeia declines have not progressed in a spatially uniform manner, and there are areas within the aforementioned lakes and Lake Superior where populations persist.  Further, Diporeia remains abundant in other lake systems despite the presence of invasive mussels.  This suggests that there may be a combination of Diporeia population characteristics and/or environmental factors that determine survival and that these vary across and within the Great Lakes.  A research team lead by Marisol Sepulveda is using new methods for measuring metabolic responses of these organisms to a number of environmental factors.  At the same time, they are investigating whether genetic differences in the declining and thriving populations may make some groups more susceptible to declines in health and numbers.  Results of the team’s first study published in Aquatic Toxicology showed that when exposed to even very small quantities of the common water pollutant atrazine (an herbicide), Diporeia collected from declining populations had very different metabolic profiles than those from thriving populations (only 5% similarity in metabolites).  This is only the first step in elucidating the underlying causes for rapid declines in this important member of the Great Lakes ecosystem.  Other studies are being conducted to look at a number of environmental and biological factors with a team of scientists from Purdue, the University of Michigan, and the State University of New York.

Proposal for Characterizing Fuel Contaminant Size and Type
Cummins Engine Foundation, $223,666
Birck Nanotechnology Center
PI: Steven T. Wereley, Mechanical Engineering
Cummins Filtration provides fuel filtration systems that are engineered to optimize fuel system protection and reduced costs. This level of expertise is obtained through several processes which include characterization of the fuel contaminants to be filtered and obtaining the necessary knowledge based on this characterization to develop a particle sensor unique to its regional contaminants.

Graduate Certificate Program in Veterinary Homeland Security
A web-based, graduate level, distance learning certificate program was developed for individuals involved in animal emergency response. Participants enhance their understanding of natural and intentional threats to animal health and strengthen their skills in management of animal-related emergencies. This activity is a cooperative effort among the Purdue University School of Veterinary Medicine, the Purdue Homeland Security Institute, the Indiana State Board of Animal Health, the Indiana State Police, the Purdue Graduate School, and Purdue University Continuing Education and Conferences. 
More than 80 professionals from 27 states, Washington D.C., Singapore and Bermuda have enrolled in the veterinary homeland security program. Participants represent the veterinary profession, government, military, academia, law enforcement and industry. Completed projects included plans for addressing animal emergencies in various communities and the identification of community resources to be used in the event of emergencies involving animals.

The Ecological Sciences & Engineering Interdisciplinary Graduate Program (ESE-IGP)
The ESE-IGP, developed by a group of faculty from across campus and facilitated by the Center for the Environment, was approved in 2003 and launched in fall of 2005.  The Ecological Sciences & Engineering Interdisciplinary Graduate Program (ESE-IGP) provides students with educational and research experiences that integrate engineering, science, policy, and life cycle thinking  concepts to addressing sustainable solutions that cut across multiple disciplines. The ESE-IGP partners with a variety of academic units that provide the discipline foundation under a set of complementary integrating themes. The ESE-IGP also serves as a catalyst to promote collaborative inter-disciplinary environmental and ecological research among Purdue University faculty members.

• The ESE-IGP is enhancing recruitment of top graduate students to Purdue in all environment-related areas at Purdue, which is benefiting multiple academic units. Faculty from 6 units within the Colleges of Agriculture, Engineering, and Science stated that the ESE-IGP applicants had higher GPAs, GRE scores, and level of maturity than applicants through their traditional department portal in their area of interest.
• Applicants increased from 7 in 2007 to 38 for 2008 (70% accepted), to over 40 prospects as of October 1, 2008 for the 2009 academic year.
• The ESE-IGP provides professional development through coursework and activities such as the ESE campus-wide symposium that attracted 175 students, faculty, and citizens last year to Purdue on the topic of sustainability.
• The overwhelmingly positive impact of the ESE-IGP on graduate recruitment and education has resulted in financial support from the Deans of the Colleges of Agriculture, Engineering, Liberal Arts, Science, and Technology and the Provost Office for the 2008-2009 academic year.

Courses that Apply for Degrees
Intensively Managed Landscapes Theme (CE 597G and GRAD 590I): This Ecological Sciences & Engineering (ESE) seminar course provides a forum for presenting current research on agricultural lands and sustainability issues by Purdue ESE faculty from across campus, while fostering dialog within the ESE community and campus wide. The course will bring additional expert speakers to Purdue, and engage students in discussion regarding grand challenges in the environment. (7 guest speakers presented to the class).

Urban & Industrial Landscapes Theme (CE 597M and GRAD 590I): This course examines sustainability issues of the urban and industrial landscape in terms of impacts on soil, water, climate, and quality of life. Students examine “mega-cities” of the world and present comparative finding of patterns of growth and impacts, with potential solutions discussed. (7 guest speakers presented to the class).

Wind Energy (ME-597W).  This Mechanical Engineering class was offered Spring 07 and in Fall 08.  Topics addressed include: Wind Farm Economics, Wind Energy Fundamentals, Wind Data Analysis, Wind Energy System Performance, Environmental Issues, and Wind Turbine Blade Design.

Biosecurity for Veterinary Responders (VCS 651):  A didactic course outlining biosecurity procedures for professionals responding to animal health emergencies. Topics include quarantine establishment, notification, personal protective equipment, general biosecurity, decontamination techniques, trace-out, collecting and mailing samples, and prevention of pathogen transmission by people and animals.

High Consequence Disease Review- Avian (VCS 646):  A didactic course presenting etiology, transmission, clinical signs, lesions, diagnostic methods and differential diagnoses for high consequence diseases that affect birds.

High Consequence Disease Review: Bovine (VCS 642):  A didactic course presenting etiology, transmission, clinical signs, lesions, diagnostic methods and differential diagnoses for high consequence diseases that affect cattle. Actual cases will be included when available.

Business Continuity Management (VCS 659):  A didactic course outlining considerations for managing business continuity during an emergency.

Global Entrepreneurship and Innovation (ENTR 390G):  The Certificate in Entrepreneurship and Innovation’s study abroad program provides students with the opportunity to learn about global entrepreneurship, innovation, product development, and opportunities for new products and services in specific global markets.  In 2007, twenty students traveled to Seoul, South Korea to meet students and faculty from prestigious educational institutions, and visit small and large companies, and relevant economic development and government organizations.  The trip was preceded by a weekly seminar on global entrepreneurship and innovation.

Risk Management in the Development of New Products and Processes (CHE 597):  Chemical Engineering, College of Engineering.  CHE 597A covers material balance concepts coupled with quantitative decision making tools which address issues related to deciding which products/processes to develop and, once selected, how to bring them to market as quickly as possible.

Fossil Fuels and Society (EAS 391):  Department of Earth and Atmospheric Sciences, College of Science. EAS 391S provides students in all majors with an in-depth understanding of the oil industry from exploration, production, and refining, to distribution and retailing. 

Business Writing for Entrepreneurs (ENGL 420E):  Department of English, College of Liberal Arts.  English 420E teaches students the rhetorical principles and writing practices necessary for producing effective business letters, business plans, memos, reports, and collaborative projects for entrepreneurial contexts. The curriculum also includes readings that cover the important roles of writing, communication, and ethics in entrepreneurship and innovation throughout a wide array of business, industry, and social contexts.

Food Processing III (FS 430):  Department of Food Science, College of Agriculture
Students work in teams to develop new food products that may be linked to existing food companies or may be proposed as the basis for a new start-up companies.

History, Ethics and Innovations of Healthcare Delivery Systems (NUR 625):  This course examines the historic and philosophic foundations to the development of the current health care delivery system. It broadens and refines the student's view of the current health care delivery system by providing an analysis, from an historical perspective, of the forces that have shaped the system, including scientific discoveries, technological advances, social justice issues, and the development of health professions and institutions. Nursing knowledge is influenced by these multiple factors; thus, the course provides students with tools to lead others in meeting the many challenges the health care system brings. The course uses a chronological and topical format that investigates policy and societal trends affecting health care, the nursing and medical professions, and professional practice. Changes in the roles of health care providers and consumers are assessed from economic, social, organizational, political, ethical, legal, and technological perspectives.

Health Policy: Local to Global (NUR 632): This course provides an overview of policy decisions related to the organization, financing, and delivery of healthcare in the global community. Social, ethical, cultural, economic, and political issues that affect the delivery of healthcare and nursing services are critically analyzed. International models for development of health policies will be examined. Roles of healthcare providers and consumers of healthcare services, as well as government and entrepreneurial interests are examined.

Health Policy Residency (NUR 673): Theories of leadership, motivation, power, and influence are used to evaluate interpersonal relationships within healthcare organizations. Theories of communication and justice, coaching, and oversight in healthcare organizations are also utilized. Students do program evaluation for improvements in clinical outcomes, efficiency, resource allocation, and cost reduction.
 
Role Transition and Synthesis (NUR 675): This course provides an integration of core, cognate, and specialty knowledge with an emphasis on role transition and synthesis. It focuses on internal and external health care organizational factors at the local, state, national, and international levels. Seminars will explore role issues, licensure, credentialing, finances, legislation, health care policy, legal issues, ethics, cultural diversity, evidence based practice, emerging trends in the management of acute and chronic conditions of adults, and independent and collaborative practice.

Medication Utilization and Patient Management (PHAD 46): The management of a pharmacy practice is governed by regulations, healthcare organization structures and decision-making by key stakeholders.  This course provides the knowledge as well as a decision-making framework and tools to permit students to effectively manage individual practices and their patients’ medication utilization.  Specific focus is on organizations and reimbursement systems involved in healthcare delivery (e.g., Medicare, Medicaid, managed care), as well as techniques used in health policy decisions (e.g., health outcomes research).  The course combines reading assignments, lectures and recitations to provide students an opportunity to learn these management principles and apply them, using practical examples of practice decisions.

Comparative Healthcare Systems (Soc 572) using cost, quality, and access to care as core concepts, this course explores healthcare in comparative context.  Special topics are health and gender, the environment, epidemics, long-term care, technology, and rationing, among others.

The Human Side of Medicine (Soc 573) focuses on sociological theory and research related to social conflicts over the delivery of healthcare in the U.S. Considers social issues pertaining to abortion, AIDS, human experimentation, reproductive technologies, euthanasia, and others.

The Social Organization of Healthcare (Soc 574): Analysis of the determinants and consequences of the social organization of medical care. Considers morbidity and mortality, costs and utilization of medical services, healthcare occupations and institutions, and change in programs and policies.  

Professional Education Courses

Boeing PLM (Product Life Cycle Manufacturing) Certificate Program, consisting of four courses: 1) Introduction to Digital Manufacturing, 2) Application of Digital Manufacturing, 3) Product Data Management, and 4) Virtual Team Development and Management

Department of Labor ETA Grant courses developed and offered through TAP:  1) Continuous Improvement in Product Development, 2) Design of Quality Processes for Advanced Manufacturing, and 3) Minimizing the Environmental Impacts of Advanced Manufacturing

Department of Labor ETA Grant courses developed and offered through EPE:  1) Factory Basics, 2) Program Management, and 3) Bridging Generational Gaps:  Maximizing Workplace Potential

Pharmaceutical Technology & Education Center courses:  1) Active Pharmaceutical Ingredient (API) Process Development, 2) Manufacturing and Design of Solid Dosage Formulations, 3) Pharmaceutical Quality by Design, and 4) Pharmaceutical Supply Chain Management

Life Sciences Competition, Spring 2007

Team Name	Team Description
Aerial Image Corporation	Aerial Image is a service based company for aerial mapping and photography for the Agriculture and telecommunications industries
Jinsitec, LLC	Jinsitec offers innovative technology to improve the quality of life for persons taking medication, effectively addressing the serious problem of global compliance.
Seyet LLC	Seyet delivers visual communication solutions that provide the most concise, clear, and accurate means for life sciences companies and researchers to communicate complex information which will engage audiences and enable them to make critical decisions. This includes investors, scientists, doctors, sales representatives, patients, and juries.
SnapFire	SnapFire will realize the promise of personalized medicine with a revolutionary approach to visualization and analyses of the huge volumes of data that characterize current biomedical research and health care delivery. A first product that will bring positive cash flow in year 2 will capture the market for proteomics and metabolomics research data analysis. Continued development at SnapFire will expand to diverse and heterogeneous data types with progressively larger markets and profit prospects.
QHeart Inc	QHeart, Inc. is a medical devices company currently commercializing the BioQ Cardiac Assist System (CAS), a unique self powered device that is designed to offer preventative and cost effective treatments to the global heart failure community.
MatrixBio	MatrixBio has developed advanced "Metabolite Profiling" technology that provides highly accurate tests for early cancer diagnosis and for following the effects of drug therapy. MatrixBio analyzes multiple small molecule biomarkers that are used to diagnose cancer at its earliest stages, providing more therapy options and better outcomes.
Cytometry for Life	Cytometry for life (C4L) was established as a not-for-profit entity to address the need for Cluster of Differentiation 4 (CD4) capabilities to deal with the impact of the HIV/AIDS epidemic in remote or rural regions that lack high-infrastructure laboratory environments. Using innovative approaches and mature technology, C4L's CD4 T-lymphocyte counter measures CD4 absolute count and percent lymphocytes in a manner that is simple to operate, portable, reliable, and battery powered.
Iprivacy Manager	The services provided by this organization will be IT Training and business/project implementation simulation.
GameSense	To create an Indiana web portal databasing all Indiana small businesses and startup companies. Portal will be in a wiki format editable by registered companies in database with the option to upgrade to websites created by Start Indiana. The ability to use tagged and filtered searches will allow a registered user to easily navigate a complete listing of all Indiana small businesses. There would also be targeted internal paid advertising options. Through advertising and sales of site upgrades an ROI could be returned and the site format would be repeatable in all 52 States allowing for increased revenue due to economies of scale bringing costs down.

The facilities afforded through Discovery Park to support research and new discoveries make a critical difference for faculty, staff, and students.  In addition to the over $100 million in buildings at Discovery Park, the tools and equipment added contribute significantly to Purdue’s research agenda.  Since all of the equipment in Discovery Park is shared, the resources here are leveraged far more broadly than is typical when discussing laboratory space and equipment.  Additionally, Discovery Park provides technical staff to support complicated and sensitive instruments and manage data. 

In 2007, Discovery Park added $1.4 million worth of equipment to the Purdue University campus, much of it in Discovery Park.  Since the inception of Discovery Park in 2001, Discovery Park has added $27 million worth of tools and equipment to our campus.  Some of the most notable equipment includes:

High throughput genetic analysis
Discovery Park has contributed to next generation sequence analysis platforms now on campus.  The SOLiD and 454 next gen sequencers provide capabilities for describing the genome sequence of new species and of genetic modifications created in the laboratory and in nature. As a compliment to these systems for determination of DNA sequencing, specific variations can be interrogated quickly, cheaply and in parallel with the GeXP analysis system in the Bindley Center. This system is an integrated platform for simultaneous detection of multiple genes or gene variants from many different samples. In the same experiment, the system can analyze DNA sequence, DNA modifications such as mutations and single nucleotide polymorphisms as well as mRNA expression.

Applications include:  (a) Detect and describe distinct species in populations of soil and water bacterial populations, (b) Characterize genetic differences in cancer cell lines exposed to anti-cancer drugs, and (c) Characterize expression of neurotransmitter receptor gene sequences in cells that model nervous system communication. The users for these two pieces of equipment are interdisciplinary.  The SOLiD system is especially important to researchers across the campus.  Discovery Park, often, is a contributing investor to enhance the purchase of equipment by Purdue.  For example, the GeXP system was purchased through a vendor award to Bindley Bioscience of $65K plus cost shares with Bindley Bioscience Center, the Oncological Sciences Center, and the Purdue Cancer Center to reach the total of $130K.

Complimentary tools for metabolomics
Characterization of the presence and quantity of small molecule metabolites in complex biological samples is the specialty of the Bindley Metabolite Profiling Facility (MPF). A suite of mass spectrometers specialized for different aspects of small molecule detection have been obtained in cooperation with investigators across campus. Lilly Endowment award funds augmented an NSF major research instrumentation award to enable the MPF to obtain multiple high sensitivity metabolomics instruments and a data handling and storage system to ensure data archiving. Two triple quadrupole mass spectrometers for ultra-high sensitivity analysis of specific metabolites in the sample were obtained in 2008 via consortium funding from 4 Purdue Colleges and the Provost’s office. The new triple quads provide direct connection of data between existing metabolomics platforms (time of flight and ion trap mass spectrometers) via the integrated nanochromatography ‘chip cube’ system that was first available for complex biological sample analysis in the Bindley center.

Applications include: (a) Detect trace concentrations of vitamin D and its analogs in human samples, (b) Define metabolites associated with muscle wasting (cachexia) in cancer patients, (c) Identify active therapeutic molecules in medicinal herbs, tea and fungi, and (d) Precisely define concentration of specific cancer biomarker proteins.  MPF users are campus wide, especially Science, Engineering, Pharmacy, Agriculture, Consumer and Family Sciences, Liberal Arts.  The purchase of the triple quadrupole mass spectrometers reflects the collaborative leveraging of Discovery Park.  The equipment was purchased via the Provost equipment matching funds in 2008 with contributions from Bindley Bioscience Center, and the Colleges of Pharmacy, Science, Agriculture and Consumer and Family Sciences (Lead unit for Provost equipment RFA) to reach the total cost of $400K.

Discovery Park awarded 20 seed grants totaling $695,000 to faculty in the Colleges of Science, Engineering, Liberal Arts, Technology, Agriculture, Nursing, Veterinary Medicine, Pharmacy, Management, and Libraries, as well as other units on campus such as the Envision Center and the Center for Wireless Systems.  Here are three examples:

Portable Immersive Virtual Learning Environment for Biotechnology Education, Kari Clase, Jenna Rickus, Nicoletta Adamo-Villani, and Aman Yadav. The proposed project will develop a tool that will be used to examine the efficacy of Virtual Reality as a mechanism for infusing the knowledge and excitement of cutting-edge research into the high school and undergraduate classroom. The tool will be used to validate an interactive module using portable immersive virtual technology to teach abstract concepts in biology and engineering. The interactive module will allow students (and teachers) to enter and manipulate the parts of a cell, discovering first hand the effects that permutations have on the system. Users will confront misconceptions as they interact within the Virtual Learning Environment. The general goal of the project is to develop professional resources and tools for the instruction of K-12 and undergraduate students and teachers in the interdisciplinary field of industrial biotechnology (integration of biology, engineering and technology) with specific applications to emerging industrial needs, such as bioenergy. The specific objective of this work is to develop an immersive, interactive, 3D-animation based Virtual Learning Environment for biotechnology education that can be delivered on low-cost portable immersive virtual reality systems. (Discovery Learning Research Center)

Life Long Analysis of Bladder Cancer Development and Patient Care:  Dog as Proxy/Surrogate to Human, Deborah W. Knapp, Department of Veterinary Clinical Sciences; Marietta Harrison, Dept. of Medicinal Chemistry and Molecular Pharmacology, and Seza Orcun, e-Enterprise Center.  The goal of this project is to develop a methodology to study complete cancer care trajectories using the care of pet dogs with naturally occurring cancer as a proxy to the delivery of human healthcare.  The long term goal is to be able to predict cancer behavior and response to therapy in the individual patient, and thus to individualize cancer care.  (Discovery Park Administration)

Self-care and Health Literacy in Telehealth and Traditional Home Health Patients with Heart Failure; PI-Karen Yehle, Nursing; Collaborating Faculty – Kimberly Plake, Pharmacy; Healthcare Partner – St Vincent Health.  Heart failure is a chronic illness that requires daily monitoring.  The current system is not designed to provide education and support.  Without education and support, patients do not develop self-care behaviors.  Management behaviors include adjusting fluid and sodium intake, and increasing the diuretic dose based on symptoms.  Another dimension of self-care is the patient’s confidence in evaluation of symptom importance, noticing health changes, taking action, and evaluation of the action taken. This study looks at self-care abilities of participants in St. Vincent’s Home Health Program, relationships between these behaviors and outcomes, and to compare telehealth to traditional home health for developing these self-care behaviors.  (Regenstrief Center for Healthcare Engineering)

Additionally, $83,980 recharge grants given in Birck Center to 14 different faculty from Colleges of Engineering, Technology, Science, and Pharmacy.

Entrepreneurial Leadership Academy
Nine Purdue University professors participated in the 2008 Entrepreneurial Leadership Academy.  The program brings faculty together with business innovators and introduces entrepreneurship ideas in the classroom. The academy is part of the Kauffman Campuses Initiative at Discovery Park's Burton D. Morgan Center for Entrepreneurship and also is supported by the Susan Bulkeley Butler Center for Leadership Excellence.  Each faculty participant received a $5,000 award to be used for entrepreneurship projects or research.  Results from these projects included publications, funded grants, new course development, and start-up companies.  A few examples are highlighted below. 

Grants
A USDA-NRI grant on family business transition,“Transfers for Strong and Sustainable Small and Medium Sized Farm Family Businesses,” was funded at $485,000 starting January 2009-December 2011.

Publications
“Open Access Book Publishing in Writing Studies: A Case Study.” (David Blakesly with Charles Bazerman, Mike Palmquist, and David Russell). First Monday. 13.1 (7 January 2008). http://www.uic.edu/htbin/cgiwrap/bin/ojs/index.php/fm/article/view/2088/1920 [10,300 words]

Start-up Initiatives
Under the guidance of a participant, a group of students recently started a new firm called ReLaunch (Responsive Launch) and are presently seeking SBIR and venture capital funds.

Course

ENTR 490, “Global Entrepreneurship and Innovation,” The course of 20 and 25 students for 2007 Korea visited and 2008 China visited, respectively. The course comprised four in-class sessions on the local cultural and economic environment, political and financial systems, and the infrastructure for promoting start-ups in a university context.  A strong emphasis was multiple company visits. Through in-depth panel discussions, students were able to learn first-hand from the entrepreneurs of the local enterprises regarding the challenges for doing business in Korea or China.

Center for Analytical Instrumentation Development (CAID)
Analytical chemistry and its instrumentation provide the measurements and quantitative information underlying much of the research and commercial activity in chemistry, biology, and medicine.  CAID has been created in Discovery Park that brings together chemists, physicists, engineers, biologists, and physicians from multiple Schools at Purdue University, University of Notre Dame, Indiana University, and the University of Illinois at Urbana-Champaign. The mission of the Center is to develop innovative “machine-tools of science” that enable discoveries across a broad spectrum of life science.  These activities will lead to routine, point-of-need devices for use in drug discovery, clinical diagnostics, environmental monitoring, and the fight against chemical and biological terrorism.  America leads the world in the development of analytical instrumentation and CAID proposes to lead America.  CAID is led by Dr. R. Graham Cooks and Dr. Fred E. Regnier of the Department of Chemistry. 

The Purdue Center for Metal Casting Research (PCMC)
The PCMC was launched in July, 2008.  The center is led by Director Kevin Trumble (Professor, Materials Engineering (MSE)) in collaboration with Prof. Qingyou Han (Mechanical Engineering Technology), Prof. Christine Corum (MET), Prof. Matthew Krane (MSE), and Prof. David Johnson (MSE).  The center will conduct interdisciplinary, industry-driven research and education programs to advance commercial metal casting practices and develop new commercial solidification processes.  The PCMC will organize consortia of specific casting industries (e.g., die-casting, re-melting) that have a strong economic presence in Indiana.  The center will operate under the umbrella of the Purdue Center for Advanced Manufacturing through which it will seek to maximize collaboration with the manufacturing research community at Purdue and across the state.  Proposals totaling over $10M in funding for the Center have been submitted to federal agencies in addition to several industry proposals. A major proposal to the Indiana Economic Development Corporation is also under preparation.

The Discovery Learning Research Center (DLRC), a research center in its own right, also provides assessment and evaluation services in support of other Centers and Units on campus, as well as external to Purdue.  DLRC Assessment activities are led by Dr. Deborah Bennett and supported by the staff and graduate students in the DLRC.  Dr. Bennett is an Associate Professor of Educational Studies in the College of Education at Purdue University and a Faculty Fellow with the Discovery Learning Research Center.  Through her funded research, Dr. Bennett has established the Assessment Research Center (ARC) to support research and development in the areas of assessment and evaluation. She currently holds a joint appointment between the Discovery Learning Center and the Purdue College of Education and ARC is co-located between College of Education and DLRC.  The Assessment Research Center, working through the DLRC, leads evaluation efforts for a number of large grants and has supported grant submission of many others by designing and implementing assessment plans, developing and validating instruments, mentoring graduate students, and managing evaluation efforts.

Funded Grants supported by DLC-ARC: HHMI Electronic Field Trips in Comparative Biology; Lilly Endowment Opportunities for Indiana; Lilly Endowment Supporting and Enhancing IfI; NASA Indiana Space Grant Consortium; NIH Interdisciplinary Cancer Prev. Research Internship Program; NSF CPATH; NSF Advance; NSF CCLI; NSF CI-TEAM; NSF NCLT; NSF Mentoring Native Americans for Success in the Geosciences; NSF GK-12; NSF S-STEM FEELS; BDM Foundation Interns for Entrepreneurship

Health Literacy Informatics Technology
Health Informatics and Learning Technologies (HILT) is an applied research and development cluster focused on improving healthcare outcomes.  Their multidisciplinary team is dedicated to supporting the patient-provider care continuum through the innovative use of information technologies, communication, and learning technologies.  Their areas of focus include telehealth, e-learning, and team collaboration.

Center for Assistive Technology
The Regenstrief Center for Healthcare Engineering (RCHE) at Purdue University was privileged to make a proposal to the Indiana Family and Social Services Administration (FSSA) regarding the building of innovation capacity in the adaptive technology (AT) market and ultimately establishing a global epicenter of AT innovation in Indiana. RCHE strongly supports the vision of the FSSA and its partners.  The Center for Assistive Technologies (CAT), is initially supported by FSSA and Purdue University, but ultimately sustained through the mobilization of the AT market.  The goal is to create market forces that sustain AT innovation for the benefit of those with disabilities and FSSA.

The Certificate for Entrepreneurship and Innovation Program, supported through Discovery Park's Burton D. Morgan Center for Entrepreneurship, is one of Discovery Park's most successful initiatives to extend student learning in non-traditional ways. Purdue undergraduates receive a "Certificate" after the completion of fifteen course hours or five courses related to entrepreneurship. The course offerings complement any major at Purdue, and students are enrolled from every College/School in the University. The requirements include two introductory courses in entrepreneurship and a capstone course.

Since the inception of the program in 2004, 131 certificates have been awarded to students: about 100 of these were awarded in 2007. Based on the program's success, a study abroad opportunity was developed; 22 students traveled to China in 2008.

The program reaches a diverse group of students. Enrollment in the introductory course, ENTR 200-Introduction to Entrepreneurship, through the spring semester 2007 reflected the following:

		Number	Percent
Male	801	76.40%
Female	248	23.60%
Caucasian	833	79.40%
Asian American	54	5.10%
African American	50	4.80%
Hispanic	25	2.40%
Native American	2	0.20%
Unreported, missing or other	85	8.10%

These Discovery Park internship programs prepare students for the leadership needs they will face tomorrow in two ways: (1) the Interns for Indiana program places student interns in start-up companies where they work as a member of the small, start-up team to make a company successful; and (2) the Discovery Undergraduate Research Internship Program places students on interdisciplinary research teams to work on cutting-edge discoveries.

The Interns for Indiana program places about 100 students per academic year in start-up companies. The majority of these students are undergraduates, but a few graduate students participate as well. This program helps to keep students in the state: of 112 students tracked, 66% accepted positions in the state of Indiana upon graduation. More than one-third of non-Indiana residents who participated in the program accepted positions in Indiana.

The Discovery Undergraduate Research Internship program also supports slightly over 100 undergraduate students annually.

The Entrepreneurial Leadership Academy, funded through a grant from the Kauffman Foundation, competitively selects ten mid-career faculty members each year to participate as Fellows. The Entrepreneurial Leadership Academy meets monthly to learn about the resources available at Purdue and the challenges of leading entrepreneurial enterprises. Some of these faculty members intend to use their entrepreneurial skills to launch a business; others intend to utilize these skills to lead new centers at Purdue, develop new research initiatives, create new courses, or assemble new grant proposals. The goals of the Academy are two-fold: (1) to provide the skills and knowledge to afford new opportunities to entrepreneurial faculty; and (2) to create an ever-expanding network of entrepreneurial faculty and leaders on our campus.

A web-based, graduate level, distance learning certificate program was developed for individuals involved in animal emergency response. Participants enhance their understanding of natural and intentional threats to animal health and strengthen their skills in management of animal-related emergencies. This activity is a cooperative effort among the Purdue University School of Veterinary Medicine, the Purdue Homeland Security Institute, the Indiana State Board of Animal Health, the Indiana State Police, the Purdue Graduate School, and Purdue University Continuing Education and Conferences.

More than 80 professionals from 27 states, Washington D.C., Singapore and Bermuda have enrolled in the veterinary homeland security program. Participants represent the veterinary profession, government, military, academia, law enforcement and industry. Completed projects included plans for addressing animal emergencies in various communities and the identification of community resources to be used in the event of emergencies involving animals.

The ESE-IGP, developed by a group of faculty from across campus and facilitated by the Center for the Environment, was approved in 2003 and launched in fall of 2005. The Ecological Sciences & Engineering Interdisciplinary Graduate Program (ESE-IGP) provides students with educational and research experiences that integrate engineering, science, policy, and life cycle thinking concepts to addressing sustainable solutions that cut across multiple disciplines. The ESE-IGP partners with a variety of academic units that provide the discipline foundation under a set of complementary integrating themes. The ESE-IGP also serves as a catalyst to promote collaborative inter-disciplinary environmental and ecological research among Purdue University faculty members.

• The ESE-IGP is enhancing recruitment of top graduate students to Purdue in all environment-related areas at Purdue, which is benefiting multiple academic units. Faculty from 6 units within the Colleges of Agriculture, Engineering, and Science stated that the ESE-IGP applicants had higher GPAs, GRE scores, and level of maturity than applicants through their traditional department portal in their area of interest.
• pplicants increased from 7 in 2007 to 38 for 2008 (70% accepted), to over 40 prospects as of October 1, 2008 for the 2009 academic year
• The ESE-IGP provides professional development through coursework and activities such as the ESE campus-wide symposium that attracted 175 students, faculty, and residents last year to Purdue on the topic of sustainability
• The overwhelmingly positive impact of the ESE-IGP on graduate recruitment and education has resulted in financial support from the Deans of the Colleges of Agriculture, Engineering, Liberal Arts, Science, and Technology and the Provost Office for the 2008-2009 academic year.

A number of external partnerships are critical to Discovery Park's abilities to infuse the use of innovative technologies and thinking into initiatives that create the leadership of the future.

Examples:

• To develop new leaders in the Science, Technology, Engineering, and Mathematics fields, Discovery Park's Discovery Learning Research Center has 28 K-12 institutional partners, 6 community college partners, and 13 university partners. Of the many programs and partnerships under the umbrella of the Discovery Learning Research Center, the Center for the Authentic Practice of Science Education enjoys partnerships with 12 institutions of higher education, including the University of Queensland in Brisbane, Australia.
• In the arena to cultivate better preparedness for pandemics on the part of many state and healthcare partners, Discovery Park's Homeland Security Institute is proud of the partnership outcome: An increase of Indiana's CDC Pandemic Preparedness Score from 38% in 2005 to 96% in 2008.
• Discovery Park's Oncological Sciences appreciates a key partnership with the Hoosier Oncology Group which includes over 400 dedicated community and research center physicians in the following states and countries: Indiana, Michigan, Missouri, Nebraska, New Jersey, Ohio, Oregon, Pennsylvania, Texas, and Lima, Peru. This partnership is key to several of the workshops and projects facilitated through the Oncological Sciences Center.

The discoveries underway by faculty associated with Discovery Park reach many parts of the world. The list below reflects funded research in India, China, and Korea. The research partnership in Korea is part of a larger collaboration with the Korean Institute of Science and Technology.

Several of the funded projects are part of longer projects. For example, Professor Tim Fisher (ME), his family (wife Amy and three children ages 9-14), and one of his doctoral advisees (Kyle Smith, BSME '07) spent nearly five months in Bangalore, India from late December 2007 to mid May 2008. Professor Fisher served as a visiting faculty member at the Jawaharlal Nehru Centre for Advanced Scientific Research, whose founder is Purdue alumnus Dr. CNR Rao, FRS (PhD Chem '58, Hon Doc.'82). Many very fruitful research collaborations emerged, including studies of hydrogen storage materials, electrically enhanced carbon nanotube structures, and hybrid organic-inorganic solar cells. This experience was also very enriching for Professor Fisher's family. The children attended a private school whose student population was nearly 100% Indian, and Amy spent several days each week teaching elementary school children at a free school that served a slum area of Bangalore.

The list reflects the collaborative nature of the funding for global research projects.

• Studies of carbon nanotube, Timothy Fisher (Purdue) and C.N.R. Rao (India). Funded by National Science Foundation and Jawaharial Nehru Center for Advanced Scientific Research, Bangalore.
• Strategic Deployment of Vehicle Detectors, Srinivas Peeta, Professor of Civil Engineering, Purdue University (PI), Shou-Ren Hu, Assistant Professor, National Cheng Kung University (Co-PI). Funded by NEXTRANS (U. S. Department of Transportation) and the National Cheng Kung University.
• Addressing Uncertainties in Travel Time Estimates using Artificial Intelligence Techniques for Intelligent Transportation Applications, Srinivas Peeta (Purdue), Partha Charkroborty, (IIT Kanpur, India). Funded by the Indo-US Science and Tech. Forum.
• Molecular Imaging and Nanomedicine for Therognosis Using Nano-Bio Materials, James Leary and Kinam Park (Purdue); Ick Chan Kwan and Kuiwon Choi, Korea Institute of Science and Technology. Korean Ministry of Science Global Research Laboratory. Funded through Global Research Award with the Korean Institute of Science and Technology.

The leadership of Discovery Park is dedicated to increasing the participation of Purdue faculty/staff/students in international activities. The representative programs listed below connect Discovery Park centers with differing parts of the world.

• Symposium on Bionanotechnology and Pharmaceuticals, 13-14 March 2008, Center for Cellular and Molecular Biology, Hyderabad India
• Joint India-US workshop on nanoscale nanomaterials for enhanced energy transport, conversion and efficiency, Jawaharlal Nehru Center for Advanced Scientific Research and J.F. Welch Technology Centre, GE Global Research, August 19-21, 2008, Bangalore, India
• 2007 China-US Joint Workshop Environmental Aspects of Bioenergy Production and Sustainability, September 11-13, 2007 in Knoxville, Tennessee, USA
• Third Annual Purdue-KIST (Korean Institute of Science and Technology) symposium for Nanomedicine and Theragnostics, June 1-4, 2008, Seoul
• Designing Cyberinfrastructure to Enable US-China Collaboration in Tobacco Research Workshop, Beijing, China, March 2008

As an early step in the path to funded research projects and student programs, Discovery Park leaders are working with several global partners to formalize these collaborations. These formal agreements will facilitate quicker and easier response times for new ideas and opportunities. These agreements also solidify the work that has already been done to create collaborative partnerships.

The following agreements have been finalized.

• (Memorandum of Understanding) Beihang University (China)
• (Nondisclosure Agreement) Center for Cellular and Molecular Biology, Hyderabad (India)
• (Nondisclosure Agreement) Tata Innovation Center, Tata Chemicals Ltd., Pune (India)
• (Memorandum of Understanding/Product Lifecycle Management Advisory Board Membership) Satyam Computer Ltd., Hyderabad (India)
• (Memorandum of Understanding) Department of Science and Technology, New Delhi (India)
• (Memorandum of Understanding) National Taiwan University (Taiwan)
• (Memorandum of Understanding) Korean Institute for Science and Technology (South Korea)
• (Master Science Research Agreement) Themework Analytics
• (Contract) BP Azerbaijan
• Satyam Computer Services Ltd. - Full Product Lifecycle Management Center of Excellence industrial advisory board membership (2008)

Global learning opportunities for students were facilitated through Discovery Park in three ways: (1) A Study Abroad Program sponsored by the Burton D. Morgan Center for Entrepreneurship for students in the Certificate in Entrepreneurship and Innovation Program; (2) Internships at global companies; and (3) research internships.

• 2008 Summer International Discovery Undergraduate Research Intern at Tata Institute of Fundamental Research/Mumbai/National Center for Biological Sciences, India, Aditi Trehan, Biological Sciences;
• Research/Mumbai/National Center for Biological Sciences, India), Rachana Raghothama, Biomedical Engineering
• Summer 2008 interns at Infosys, India
  • Devanshu Singh - Software Engineer and Technologies Lab unit, Purdue Calumet-Engineering, Science and Math;
  • Gautam Agarwal - Product Lifecycle and Engineering Labs unit;
  • Manish Kumar - Software Engineer and Technologies Lab unit, Mathematics;
  • Smriti Bajaj - Software Engineer and Technologies Lab unit, Purdue Calumet-Engineering, Science and Math;
  • Tejas Kulkarni - Software Engineer and Technologies Lab unit, Electrical and Computer Engineering
• Summer 2007 interns at Infosys, India,
  • Benny Leong, College of Technology
  • Mohmmad Siddiqui, Computer Science
• In May 2008, twenty-five undergraduate students were part of a Purdue global entrepreneurship program designed to provide students with an understanding of business and innovation in China as well as to understand what it's like to live and work in China. Students participated in an April seminar and then a Maymester study abroad to Beijing, China for two weeks.

Discovery Park affiliated faculty avidly involve their graduate students in global learning opportunities. Often, this involves funding for these students to participate in international workshops and conferences. Here are representative examples of global graduate students' research projects.

• Advanced Modern Biology Program in 2007 and 2008, Mumbai, Enge Langhor (VM); Jacob Hale (Physics)
• 2008 Sustainable Development and Climate Change, Delhi, India, Dileep Birur (Agriculture); Kyle Smith (Mechanical Engineering); C.K. Castillo (Earth and Atmospheric Sciences)
• 2008 Bionanotechnology and Pharmaceuticals, Hyderabad, India, David Jaroch (Biomedical Engineering); Felice Butler (Pharmacy)
• 2008 Scalable Nanomaterials Research Symposium, Bangalore, India, Aaron Franklin; Scott; B. Cola; Jeremy Schroeder, D. Pandey; H. M. Aktulga; G. Prakash; K. Biswas; Kyle Smith
• 2008 Summer International Discovery Undergraduate Research Internship at Purdue, Rubul Mout and Sujaan Das, Tata Institute for Fundamental Research, India

Discovery Park affiliated faculty are active participants in the global research community. This work informs their research initiatives and those of their global partners.

• Brian Rinner (Forestry & Natural Resources) and Caleb Phillips (Forestry & Natural Resources) conduct research in Azerbaijan and Russia, respectively
• Geoff Laban (Forestry & Natural Resources) participated in the NanoECO International Conference in Monte Verita, Switzerland March 2-7, 2008)
• T. Fisher (sabbatical), India
• J. Irudayaraj; J. Leary; P. Basu; P. Sharma; C. Buck; Y. Yeo; S. Byrn; C. Svensson (all participated in the Bionanotechnology symposium in Hyderabad, India)
• M. Abu-Omar; A. Alam; V. Balakrishnan; S. Datta; S. Garimella; D. Janes; R. Reifenberger; P. Sharma; T. Sands; L. Stanciu. Participated in a "Joint India-US Workshop on Scalable Nanomaterials for Enhanced Energy, Transport, Conversion, and Efficiency"in August 2008, Bangalore, India.
• Ned Howell (Satyam, Hyderabad visit)
• G. Cooks (Dec 2007 visit to India)
• Amy Childress, Barb Fossum, and Jim McGlothlin (International Programs Global Partners Grant to India, summer 2007 visit)
• Gabriela Weaver spent two months in Australia setting up a CASPiE partnership
• Jeong-Gyu Kim (visiting scientists from Korea, hosted by Linda Lee)
• John Bickham, Ryan Hubinger are part of the International Whaling Commission meetings
• (Spring 2008) Nan Kong, RCHE faculty and assistant professor in biomedical engineering, hosted visiting scholar Lei Zhao, Ph.D. from Tsinghua University, Beijing, China as part of a Visiting Indian and Chinese Scholars grant through Purdue's Office of International Programs.
• Ahmed Elmagarmid, Qatar University
• Rudolf Eigenmann, Waseda University, Japan (2/08); Barcelona Super Computing Center, Barcelona, Spain (1/08); Kampur, India (12/07); Switzerland, Spain, Italy (5/08)
• Barb Fossum, Mumbai, Delhi, Bangalore, India (8/07); Beijing, China (3/08); Hong Kong, China (6/08)

As Discovery Park affiliated faculty become more integrated into the global research community through many of the initiatives listed in this report, their collaboration on scholarly publications will continue to increase. Here are two identified for the 2007 calendar year.

• Dirk Schweitzer, Junyi Zhu, Gotam K. Jarori, Junichi Tanaka, Tatsuo Higa, Vincent Jo Davisson & Paul Helquist, Synthesis of carbamate derivatives of iejimalides. Retention of normal antiproliferative activity and localization of binding in cancer cells (2007) Bioorganic & Medicinal Chemistry 15, 3208-3216
• Santonu Sarkar, Girish Maskeri Rama, and Avinash C. Kak, API-Based and Information-Theoretic Metrics for Measuring the Quality of Software Modularization, IEEE Transactions on Software Engineering, Vol. 33, No. 1, January 2007